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Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.
Svardal, Hannes; Jasinska, Anna J; Apetrei, Cristian; Coppola, Giovanni; Huang, Yu; Schmitt, Christopher A; Jacquelin, Beatrice; Ramensky, Vasily; Müller-Trutwin, Michaela; Antonio, Martin; Weinstock, George; Grobler, J Paul; Dewar, Ken; Wilson, Richard K; Turner, Trudy R; Warren, Wesley C; Freimer, Nelson B; Nordborg, Magnus.
Afiliación
  • Svardal H; Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Vienna, Austria.
  • Jasinska AJ; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.
  • Apetrei C; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Coppola G; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Huang Y; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Schmitt CA; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.
  • Jacquelin B; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
  • Ramensky V; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Müller-Trutwin M; Department of Anthropology, Boston University, Boston, Massachusetts, USA.
  • Antonio M; Institut Pasteur, Unité HIPER, Paris, France.
  • Weinstock G; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.
  • Grobler JP; Moscow Institute of Physics and Technology, Dolgoprudny, Russian Federation.
  • Dewar K; Institut Pasteur, Unité HIPER, Paris, France.
  • Wilson RK; Medical Research Council (MRC), The Gambia Unit, The Gambia.
  • Turner TR; Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
  • Warren WC; Department of Genetics, University of the Free State, Bloemfontein, South Africa.
  • Freimer NB; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
  • Nordborg M; Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Nat Genet ; 49(12): 1705-1713, 2017 Dec.
Article en En | MEDLINE | ID: mdl-29083404
Vervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adaptación Fisiológica / Chlorocebus aethiops / Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2017 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adaptación Fisiológica / Chlorocebus aethiops / Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2017 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos