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Impact of local heating and cooling on skeletal muscle transcriptional response related to myogenesis and proteolysis.
Zak, Roksana B; Hassenstab, B M; Zuehlke, L K; Heesch, M W S; Shute, R J; Laursen, T L; LaSalle, D T; Slivka, D R.
Afiliación
  • Zak RB; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA. rzak@unomaha.edu.
  • Hassenstab BM; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
  • Zuehlke LK; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
  • Heesch MWS; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
  • Shute RJ; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
  • Laursen TL; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
  • LaSalle DT; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
  • Slivka DR; Exercise Physiology Laboratory, School of Health and Kinesiology, University of Nebraska-Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
Eur J Appl Physiol ; 118(1): 101-109, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29080996
PURPOSE: To determine the impact of local muscle heating and cooling on myogenic and proteolytic gene responses following resistance exercise. METHODS: Recreationally trained males (n = 12), age 25.3 ± 1.5, % body fat 13.6 ± 1.92, completed four sets of 8-12 repetitions of unilateral leg press and leg extension while heating one leg, and cooling the other. Muscle biopsies were taken from the vastus lateralis of each leg pre and 4 h post exercise. RESULTS: MyoD, FOXO1, and MuRF1 mRNA increased with exercise regardless of temperature (p < 0.05). Myostatin, MYF5, and atrogin-1 mRNA decreased with exercise regardless of temperature (p < 0.05). Myogenin, MRF4, and CASP3 mRNA were higher in the hot condition, compared to the cold (p < 0.05). PAX7 mRNA was lower in the hot compared to cold condition (p = 0.041). FOXO3 mRNA was higher in the cold compared to hot condition (p = 0.037). AKT1 and AKT2 were unaffected by either exercise or temperature. Femoral artery blood flow volume was higher in the hot (375.2 ± 41.2 ml min- 1), compared to the cold condition (263.5 ± 23.9 ml min- 1), p = 0.01. Tissue oxygen saturation was higher in the hot (71.7 ± 4.8%) than cold condition (55.3 ± 5.0%). CONCLUSION: These results suggest an impaired muscle growth response with local cold application compared to local heat application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Músculo Esquelético / Desarrollo de Músculos / Proteolisis / Hipertermia Inducida / Hipotermia Inducida / Proteínas Musculares Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Músculo Esquelético / Desarrollo de Músculos / Proteolisis / Hipertermia Inducida / Hipotermia Inducida / Proteínas Musculares Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania