Intravenous self-administration of the indirect dopaminergic agonist amfonelic acid by rats.
Pharmacol Biochem Behav
; 31(3): 623-6, 1988 Nov.
Article
en En
| MEDLINE
| ID: mdl-2908003
The reinforcing properties of amfonelic acid, a nonamphetamine psychostimulant, were evaluated in an intravenous self-administration paradigm. Rats were trained to self-administer cocaine (0.5-3.0 mg/kg/infusion) on a fixed-ratio 10 schedule of reinforcement via surgically implanted intravenous catheters during daily 4-hr sessions. Substitution of amfonelic acid (0.0625-0.250 mg/kg/infusion) reliably maintained self-administration in a dose-dependent manner. These data indicate that amfonelic acid can act as a reinforcer in rats, and further suggest that amfonelic acid may have abuse potential in humans.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Dopaminérgicos
/
Naftiridinas
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1988
Tipo del documento:
Article
Pais de publicación:
Estados Unidos