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Prognostic value of change in anti-thyroglobulin antibodies after thyroidectomy in patients with papillary thyroid carcinoma.
Ernaga-Lorea, A; Hernández-Morhain, M C; Anda-Apiñániz, E; Pineda-Arribas, J J; Migueliz-Bermejo, I; Eguílaz-Esparza, N; Irigaray-Echarri, A.
Afiliación
  • Ernaga-Lorea A; Department of Endocrinology, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Navarra, Spain. andernaga@gmail.com.
  • Hernández-Morhain MC; Department of Endocrinology, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain.
  • Anda-Apiñániz E; Department of Endocrinology, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
  • Pineda-Arribas JJ; Department of Endocrinology, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
  • Migueliz-Bermejo I; Department of Endocrinology, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
  • Eguílaz-Esparza N; Department of Endocrinology, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
  • Irigaray-Echarri A; Department of Endocrinology, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Navarra, Spain.
Clin Transl Oncol ; 20(6): 740-744, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29071517
PURPOSE: Anti-thyroglobulin antibodies (TgAb) can be used as a surrogate tumor marker in the follow-up of papillary thyroid carcinoma (PTC). We try to determine if the change in TgAb levels in the first post-operative year is a good predictor of persistence/recurrence risk in TgAb-positive PTC patients. METHODS/PATIENTS: 105 patients with PTC who underwent thyroidectomy between 1988 and 2014 were enrolled. We calculated the percentage of change in TgAb levels with the first measurement at 1-2 months after surgery and the second one at 12-14 months. RESULTS: TgAb negativization was observed in 29 patients (27.6%), a decrease of more than 50% was observed in 57 patients (54.3%), less than 50% in 12 patients (11.4%) and in 7 patients (6.7%) the TgAb level had increased. The percentage of persistence/recurrence was 0, 8.8, 16.7 and 71.4% in each group, respectively (p < 0.001). In the multivariate analysis, only the percentage of change in TgAb showed a significant association with the risk of persistence/recurrence, regardless of other factors such as age, size and TNM stages. CONCLUSIONS: Changes in TgAb levels in the first year after surgery can predict the risk of persistence/recurrence of TgAb-positive PTC patients. Patients who achieved negativization of TgAb presented an excellent prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Tiroidectomía / Neoplasias de la Tiroides / Carcinoma Papilar / Biomarcadores de Tumor / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Tiroidectomía / Neoplasias de la Tiroides / Carcinoma Papilar / Biomarcadores de Tumor / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia