Your browser doesn't support javascript.
loading
Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren's syndrome.
Blochowiak, Katarzyna J; Olewicz-Gawlik, Anna; Trzybulska, Dorota; Nowak-Gabryel, Michalina; Kociecki, Jaroslaw; Witmanowski, Henryk; Sokalski, Jerzy.
Afiliación
  • Blochowiak KJ; Department of Oral Surgery, Poznan University of Medical Sciences, Poland.
  • Olewicz-Gawlik A; Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland.
  • Trzybulska D; Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland.
  • Nowak-Gabryel M; Department of Ophthalmology, Poznan University of Medical Sciences, Poland.
  • Kociecki J; Department of Ophthalmology, Poznan University of Medical Sciences, Poland.
  • Witmanowski H; Department of Plastic, Reconstructive and Aesthetic Surgery, Nicolaus Copernicus University Torun, Collegium Medicum, Bydgoszcz, Poland.
  • Sokalski J; Department of Oral Surgery, Poznan University of Medical Sciences, Poland.
Adv Clin Exp Med ; 26(5): 835-842, 2017 Aug.
Article en En | MEDLINE | ID: mdl-29068581
BACKGROUND: Typical features of Sjögren's syndrome (SS) are severe xerostomia and xerophthalmia which are basic diagnostic criteria. OBJECTIVES: The aim of this study was to compare the serum levels of soluble (s) intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1) and sE-selectin between primary (pSS), secondary (sSS) and healthy subjects (HS). We correlated these results with selected clinical parameters of disease activity and parameters of the severity of xerostomia and xerophthalmia. MATERIAL AND METHODS: The serum levels of sICAM-1, sVCAM-1 and sE-selectin were determined by enzyme-linked immunosorbent assay (ELISA) in 16 patients with pSS, 18 with sSS and 15 HS. Eye dryness and xerostomia were assessed by the Schirmer's test, the Fox test and the visual analogue scale (VAS). RESULTS: The levels of sICAM-1 in pSS and sVCAM-1 in sSS patients were significantly higher when compared to HS (p = 0.02 and p = 0.048, respectively). There were no differences between pSS and sSS. In pSS, sVCAM-1 correlated positively with VAS (rS = 0.52, p = 0.04) and the Fox test (rS = 0.66, p=0.01). In sSS, sE-selectin correlated positively with sICAM-1 (rS = 0.54, p = 0.01), the duration of the disease (rS = 0.51, p = 0.03) and negatively with the Schirmer's test (rS = 0.59, p = 0.04). sICAM-1 correlated positively with the erythrocyte sedimentation rate (ESR) value (rS = 0.59, p = 0.01). CONCLUSIONS: sVCAM-1 reflects xerostomia in pSS. sICAM-1 and sE-selectin may be additional parameters of sSS activity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Sjögren / Molécula 1 de Adhesión Intercelular / Molécula 1 de Adhesión Celular Vascular / Selectina E Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Adv Clin Exp Med Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Sjögren / Molécula 1 de Adhesión Intercelular / Molécula 1 de Adhesión Celular Vascular / Selectina E Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Adv Clin Exp Med Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia