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Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes.
Dunmore, Simon J; Al-Derawi, Amr S; Nayak, Ananth U; Narshi, Aruna; Nevill, Alan M; Hellwig, Anne; Majebi, Andrew; Kirkham, Paul; Brown, James E; Singh, Baldev M.
Afiliación
  • Dunmore SJ; Diabetes Research Group, Academic Institute of Medicine, University of Wolverhampton, Wolverhampton, U.K. s.dunmore@wlv.ac.uk.
  • Al-Derawi AS; Diabetes Research Group, Academic Institute of Medicine, University of Wolverhampton, Wolverhampton, U.K.
  • Nayak AU; Department of Endocrinology and Diabetes, University Hospital of North Midlands NHS Trust, Stoke-on-Trent, U.K.
  • Narshi A; Diabetes Research Group, Academic Institute of Medicine, University of Wolverhampton, Wolverhampton, U.K.
  • Nevill AM; Faculty of Health, Education and Wellbeing, Institute of Sport, University of Wolverhampton, Walsall, U.K.
  • Hellwig A; Food Chemistry, Technische Universität Dresden, Dresden, Germany.
  • Majebi A; Diabetes Research Group, Academic Institute of Medicine, University of Wolverhampton, Wolverhampton, U.K.
  • Kirkham P; Faculty of Science and Engineering, Department of Biomedical Science and Physiology, University of Wolverhampton, Wolverhampton, U.K.
  • Brown JE; Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Birmingham, U.K.
  • Singh BM; Diabetes Research Group, Academic Institute of Medicine, University of Wolverhampton, Wolverhampton, U.K.
Diabetes ; 67(1): 131-136, 2018 01.
Article en En | MEDLINE | ID: mdl-29066600
The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in deglycation in turn leading to altered production of advanced glycation end products (AGEs). We hypothesized that variations in the level of the deglycating enzyme fructosamine-3-kinase (FN3K) might be associated with the GGap. We measured erythrocyte FN3K concentrations and enzyme activity in a population dichotomized for a large positive or negative GGap. FN3K protein was higher and we found a striking threefold greater activity (323%) at any given FN3K protein level in the erythrocytes of the negative-GGap group compared with the positive-GGap group. This was associated with lower AGE levels in the negative-GGap group (79%), lower proinflammatory adipokines (leptin-to-adiponectin ratio) (73%), and much lower prothrombotic PAI-1 levels (19%). We conclude that FN3K may play a key role in the GGap and thus diabetes complications such that FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide a novel approach to their prevention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor de Grupo Alcohol) / Diabetes Mellitus Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor de Grupo Alcohol) / Diabetes Mellitus Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos