Your browser doesn't support javascript.
loading
Does smoking habit increase the micronuclei frequency in the oral mucosa of adults compared to non-smokers? A systematic review and meta-analysis.
de Geus, Juliana Larocca; Wambier, Letícia Maíra; Bortoluzzi, Marcelo Carlos; Loguercio, Alessandro D; Kossatz, Stella; Reis, Alessandra.
Afiliación
  • de Geus JL; Department of Dentistry, School of Dentistry, Paulo Picanço Faculty, Fortaleza, CE, Brazil.
  • Wambier LM; Department of Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.
  • Bortoluzzi MC; Department of Stomatology, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.
  • Loguercio AD; Department of Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.
  • Kossatz S; Department of Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.
  • Reis A; Department of Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil. reis_ale@hotmail.com.
Clin Oral Investig ; 22(1): 81-91, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29063385
OBJECTIVES: A systematic review of clinical studies to evaluate the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients was performed. MATERIALS AND METHODS: A comprehensive search was carried out on MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO, and Cochrane Library and SIGLE without restrictions. Dissertations and thesis were searched using the ProQuest Dissertations and Periodicos Capes Thesis Databases. We included only cross-sectional clinical trials that compared the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients. DATA: After the removal of duplicates, 1338 articles were identified. After title and abstract screening, 35 studies remained. Eighteen studies were further excluded, whereas 17 studies remained for qualitative analysis and 16 for the meta-analysis of the primary and secondary outcomes. A significant difference in the frequency of micronuclei in smokers when compared to non-smokers was observed in the present study. CONCLUSIONS: Despite the high variation in the methodology of the assessed studies, this study showed a higher frequency of micronuclei in exfoliated cells of smokers compared to non-smokers. CLINICAL SIGNIFICANCE: The use of tobacco is associated with cytotoxic and genotoxic effects because a higher frequency of micronuclei in exfoliated cells of smokers was observed.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Micronúcleos / Fumar / Mucosa Bucal Tipo de estudio: Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: Clin Oral Investig Asunto de la revista: ODONTOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Micronúcleos / Fumar / Mucosa Bucal Tipo de estudio: Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: Clin Oral Investig Asunto de la revista: ODONTOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania