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Influence of the milling parameters on the nucleophilic substitution reaction of activated ß-cyclodextrins.
Jicsinszky, László; Tuza, Kata; Cravotto, Giancarlo; Porcheddu, Andrea; Delogu, Francesco; Colacino, Evelina.
Afiliación
  • Jicsinszky L; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, via P. Giuria 9, 10125 Turin, Italy.
  • Tuza K; Cyclolab Cyclodextrin R&D Laboratory, Ltd., Illatos út 7, 1192 Budapest, Hungary.
  • Cravotto G; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, via P. Giuria 9, 10125 Turin, Italy.
  • Porcheddu A; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS 554 bivio per Sestu, 09028 Monserrato (Ca), Italy.
  • Delogu F; Dipartimento di Ingegneria Meccanica, Chimica, e dei Materiali, Università degli Studi di Cagliari, via Marengo 2, 09123 Cagliari, Italy.
  • Colacino E; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, via P. Giuria 9, 10125 Turin, Italy.
Beilstein J Org Chem ; 13: 1893-1899, 2017.
Article en En | MEDLINE | ID: mdl-29062408
The present work focuses on the mechanochemical preparation of industrially important ß-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Beilstein J Org Chem Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Beilstein J Org Chem Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania