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Current immunogenetic predisposition to tuberculosis in the Moroccan population.
Qrafli, M; Najimi, M; Elaouad, R; Sadki, K.
Afiliación
  • Qrafli M; Physiopathology Team, Immunogenomic and Bioinformatic Unit, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco.
  • Najimi M; Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.
  • Elaouad R; School of Medicine and Pharmacy Sciences, Mohammed V University of Rabat, Rabat, Morocco.
  • Sadki K; Physiopathology Team, Immunogenomic and Bioinformatic Unit, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco.
Int J Immunogenet ; 44(6): 286-304, 2017 Dec.
Article en En | MEDLINE | ID: mdl-29057608
Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Predisposición Genética a la Enfermedad / Inmunogenética Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Int J Immunogenet Asunto de la revista: ALERGIA E IMUNOLOGIA / GENETICA Año: 2017 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Predisposición Genética a la Enfermedad / Inmunogenética Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Int J Immunogenet Asunto de la revista: ALERGIA E IMUNOLOGIA / GENETICA Año: 2017 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Reino Unido