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Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells.
Gomzikova, Marina O; Zhuravleva, Margarita N; Miftakhova, Regina R; Arkhipova, Svetlana S; Evtugin, Vladimir G; Khaiboullina, Svetlana F; Kiyasov, Andrey P; Persson, Jenny L; Mongan, Nigel P; Pestell, Richard G; Rizvanov, Albert A.
Afiliación
  • Gomzikova MO; Kazan Federal University, Kazan, 420008, Russia.
  • Zhuravleva MN; Kazan Federal University, Kazan, 420008, Russia.
  • Miftakhova RR; Kazan Federal University, Kazan, 420008, Russia.
  • Arkhipova SS; Kazan Federal University, Kazan, 420008, Russia.
  • Evtugin VG; Kazan Federal University, Kazan, 420008, Russia.
  • Khaiboullina SF; Kazan Federal University, Kazan, 420008, Russia.
  • Kiyasov AP; Department of Microbiology and Immunology, University of Nevada, Reno, Nevada, 89557, USA.
  • Persson JL; Kazan Federal University, Kazan, 420008, Russia.
  • Mongan NP; Department of Translational Medicine, Lund University, 205 02 Malmö, and Department of Molecular Biology, 901 87 Umeå, Umeå University.
  • Pestell RG; Cancer Biology and Translational Research, School of Veterinary Medicine and Science, University of Nottingham, LE12 5RD, UK.
  • Rizvanov AA; Department of Pharmacology, Weill Cornell Medicine, 1300 York Ave., New York, NY, 10065, USA.
Oncotarget ; 8(41): 70496-70507, 2017 Sep 19.
Article en En | MEDLINE | ID: mdl-29050297
Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis in vitro and in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos