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USP7 small-molecule inhibitors interfere with ubiquitin binding.
Kategaya, Lorna; Di Lello, Paola; Rougé, Lionel; Pastor, Richard; Clark, Kevin R; Drummond, Jason; Kleinheinz, Tracy; Lin, Eva; Upton, John-Paul; Prakash, Sumit; Heideker, Johanna; McCleland, Mark; Ritorto, Maria Stella; Alessi, Dario R; Trost, Matthias; Bainbridge, Travis W; Kwok, Michael C M; Ma, Taylur P; Stiffler, Zachary; Brasher, Bradley; Tang, Yinyan; Jaishankar, Priyadarshini; Hearn, Brian R; Renslo, Adam R; Arkin, Michelle R; Cohen, Frederick; Yu, Kebing; Peale, Frank; Gnad, Florian; Chang, Matthew T; Klijn, Christiaan; Blackwood, Elizabeth; Martin, Scott E; Forrest, William F; Ernst, James A; Ndubaku, Chudi; Wang, Xiaojing; Beresini, Maureen H; Tsui, Vickie; Schwerdtfeger, Carsten; Blake, Robert A; Murray, Jeremy; Maurer, Till; Wertz, Ingrid E.
Afiliación
  • Kategaya L; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Di Lello P; Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA.
  • Rougé L; Department of Structural Biology, Genentech, South San Francisco, California 94080, USA.
  • Pastor R; Department of Structural Biology, Genentech, South San Francisco, California 94080, USA.
  • Clark KR; Department of Discovery Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Drummond J; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California 94080, USA.
  • Kleinheinz T; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California 94080, USA.
  • Lin E; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California 94080, USA.
  • Upton JP; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Prakash S; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Heideker J; Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA.
  • McCleland M; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Ritorto MS; Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA.
  • Alessi DR; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Trost M; Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA.
  • Bainbridge TW; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Kwok MCM; Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA.
  • Ma TP; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Stiffler Z; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Brasher B; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 1HH, UK.
  • Tang Y; Department of Protein Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Jaishankar P; Department of Protein Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Hearn BR; Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, California 94080, USA.
  • Renslo AR; Boston Biochem, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA.
  • Arkin MR; Boston Biochem, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA.
  • Cohen F; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California 94143, USA.
  • Yu K; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California 94143, USA.
  • Peale F; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California 94143, USA.
  • Gnad F; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California 94143, USA.
  • Chang MT; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California 94143, USA.
  • Klijn C; Department of Discovery Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Blackwood E; Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, California 94080, USA.
  • Martin SE; Department of Research Pathology, Genentech, South San Francisco, California 94080, USA.
  • Forrest WF; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California 94080, USA.
  • Ernst JA; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California 94080, USA.
  • Ndubaku C; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California 94080, USA.
  • Wang X; Department of Translational Oncology, Genentech, South San Francisco, California 94080, USA.
  • Beresini MH; Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.
  • Tsui V; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California 94080, USA.
  • Schwerdtfeger C; Department of Protein Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Blake RA; Department of Discovery Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Murray J; Department of Discovery Chemistry, Genentech, South San Francisco, California 94080, USA.
  • Maurer T; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California 94080, USA.
  • Wertz IE; Department of Discovery Chemistry, Genentech, South San Francisco, California 94080, USA.
Nature ; 550(7677): 534-538, 2017 10 26.
Article en En | MEDLINE | ID: mdl-29045385
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Piridinas / Ubiquitina / Peptidasa Específica de Ubiquitina 7 / Aminopiridinas / Indazoles Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nature Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Piridinas / Ubiquitina / Peptidasa Específica de Ubiquitina 7 / Aminopiridinas / Indazoles Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nature Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido