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Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure.
Vella, Joseph B; Trombetta, Ryan P; Hoffman, Michael D; Inzana, Jason; Awad, Hani; Benoit, Danielle S W.
Afiliación
  • Vella JB; Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
  • Trombetta RP; Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642.
  • Hoffman MD; Department of Otolaryngology, University of Rochester Medical Center, Rochester, New York 14642.
  • Inzana J; Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
  • Awad H; Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642.
  • Benoit DSW; Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
J Biomed Mater Res A ; 106(3): 663-672, 2018 03.
Article en En | MEDLINE | ID: mdl-29044984
Biphasic calcium phosphate scaffolds formed via three dimensional (3D) printing technology to exhibit porosity and chemical resorbability to promote osseointegration often lack the strength and toughness required to withstand loading in bone tissue engineering applications. Herein, sintering and CaP:poly(caprolactone) (PCL) composite formation were explored to improve 3D printed scaffold strength and toughness. Hydroxyapatite and α-tricalcium phosphate (α-TCP) biphasic calcium powders were printed using phosphoric acid binder, which generated monetite and hydroxyapatite scaffolds. Upon sintering, evolution of ß-TCP was observed along with an increase in flexural strength and modulus but no effect on fracture toughness was observed. Furthermore, scaffold porosity increased with sintering. Additionally, two techniques of PCL composite formation were employed: postprint precipitation and 3D print codeposition to further augment scaffold mechanical properties. While both techniques significantly improved flexural strength, flexural modulus, and fracture toughness under most conditions explored, precipitation yielded more substantial increases in these properties, which is attributed to better continuity of the PCL phase. However, precipitation also compromised surface porosity due to PCL passivation of the calcium phosphate surface, which may subsequently hinder scaffold integration and bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 663-672, 2018.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Ensayo de Materiales / Fosfatos de Calcio / Fenómenos Mecánicos / Impresión Tridimensional Idioma: En Revista: J Biomed Mater Res A Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Ensayo de Materiales / Fosfatos de Calcio / Fenómenos Mecánicos / Impresión Tridimensional Idioma: En Revista: J Biomed Mater Res A Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos