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Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.
Kelly, S; Jahanshad, N; Zalesky, A; Kochunov, P; Agartz, I; Alloza, C; Andreassen, O A; Arango, C; Banaj, N; Bouix, S; Bousman, C A; Brouwer, R M; Bruggemann, J; Bustillo, J; Cahn, W; Calhoun, V; Cannon, D; Carr, V; Catts, S; Chen, J; Chen, J-X; Chen, X; Chiapponi, C; Cho, Kl K; Ciullo, V; Corvin, A S; Crespo-Facorro, B; Cropley, V; De Rossi, P; Diaz-Caneja, C M; Dickie, E W; Ehrlich, S; Fan, F-M; Faskowitz, J; Fatouros-Bergman, H; Flyckt, L; Ford, J M; Fouche, J-P; Fukunaga, M; Gill, M; Glahn, D C; Gollub, R; Goudzwaard, E D; Guo, H; Gur, R E; Gur, R C; Gurholt, T P; Hashimoto, R; Hatton, S N; Henskens, F A.
Afiliación
  • Kelly S; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Jahanshad N; Harvard Medical School, Boston, MA, USA.
  • Zalesky A; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Kochunov P; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
  • Agartz I; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Alloza C; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Andreassen OA; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
  • Arango C; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Banaj N; University of Edinburgh, Edinburgh, UK.
  • Bouix S; University of Oslo, Oslo, Norway.
  • Bousman CA; Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
  • Brouwer RM; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Bruggemann J; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Bustillo J; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
  • Cahn W; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
  • Calhoun V; Department of General Practice, The University of Melbourne, Parkville, VIC, Australia.
  • Cannon D; Swinburne University of Technology, Melbourne, VIC, Australia.
  • Carr V; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Catts S; Neuroscience Research Australia and School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
  • Chen J; University of New Mexico, Albuquerque, NM, USA.
  • Chen JX; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Chen X; The Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA.
  • Chiapponi C; The Mind Research Network, Albuquerque, NM, USA.
  • Cho KK; Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
  • Ciullo V; Neuroscience Research Australia and School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
  • Corvin AS; Discipline of Psychiatry, School of Medicine, University of Queensland, Herston, QLD, Australia.
  • Crespo-Facorro B; Department of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA.
  • Cropley V; Beijing Huilongguan Hospital, Beijing, China.
  • De Rossi P; Worldwide Research and Development, Pfizer, Cambridge, MA, USA.
  • Diaz-Caneja CM; Santa Lucia Foundation, Rome, Italy.
  • Dickie EW; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Ehrlich S; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Fan FM; Department of Psychiatry and Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
  • Faskowitz J; University Hospital Marqués de Valdecilla, IDIVAL, Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain.
  • Fatouros-Bergman H; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
  • Flyckt L; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
  • Ford JM; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Fouche JP; Department NESMOS, Faculty of Medicine and Psychology, University 'Sapienza' of Rome, Rome, Italy.
  • Fukunaga M; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
  • Gill M; Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
  • Glahn DC; Center for Addiction and Mental Health, Toronto, ON, Canada.
  • Gollub R; Division of Psychological and Social Medicine and Developmental Neurosciences, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
  • Goudzwaard ED; Beijing Huilongguan Hospital, Beijing, China.
  • Guo H; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Gur RE; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
  • Gur RC; University of New South Wales, School of Psychiatry, Sydney, NSW, Australia.
  • Gurholt TP; The University of Queensland, Queensland Brain Institute and Centre for Advanced Imaging, Brisbane, QLD, Australia.
  • Hashimoto R; University of California, VAMC, San Francisco, CA, USA.
  • Hatton SN; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
  • Henskens FA; Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
Mol Psychiatry ; 23(5): 1261-1269, 2018 05.
Article en En | MEDLINE | ID: mdl-29038599
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Sustancia Blanca Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Sustancia Blanca Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido