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Fiber-reinforced silicone for tracheobronchial stents: An experimental study.
Vearick, Samanta Bianchi; Demétrio, Kétner Bendo; Xavier, Rogério Gastal; Moreschi, Alexandre Heitor; Muller, André Frotta; Sanches, Paulo Roberto Stefani; Dos Santos, Luis Alberto Loureiro.
Afiliación
  • Vearick SB; Biomaterials Laboratory, Universidade Federal do Rio Grande do Sul, School of Engineering, Av. Bento Gonçalves, 9500, Setor IV, Prédio 74 / sala 18, Campus do Vale, Bairro Agronomia, CEP 91509-900 Porto Alegre, RS, Brazil.
  • Demétrio KB; PPGCEM, Post-Graduate Program in Science and Engineering Materials, UNESC - University of the South of Santa Catarina, CEP 88806-000 Criciúma, SC, Brazil. Electronic address: ketnerbd@gmail.com.
  • Xavier RG; Clinical Hospital of Porto Alegre, Rua Ramiro Barcelos, 2350, Bairro Rio Branco, CEP 90035-903 Porto Alegre, RS, Brazil.
  • Moreschi AH; Clinical Hospital of Porto Alegre, Rua Ramiro Barcelos, 2350, Bairro Rio Branco, CEP 90035-903 Porto Alegre, RS, Brazil.
  • Muller AF; Clinical Hospital of Porto Alegre, Rua Ramiro Barcelos, 2350, Bairro Rio Branco, CEP 90035-903 Porto Alegre, RS, Brazil.
  • Sanches PRS; Clinical Hospital of Porto Alegre, Rua Ramiro Barcelos, 2350, Bairro Rio Branco, CEP 90035-903 Porto Alegre, RS, Brazil.
  • Dos Santos LAL; Biomaterials Laboratory, Universidade Federal do Rio Grande do Sul, School of Engineering, Av. Bento Gonçalves, 9500, Setor IV, Prédio 74 / sala 18, Campus do Vale, Bairro Agronomia, CEP 91509-900 Porto Alegre, RS, Brazil.
J Mech Behav Biomed Mater ; 77: 494-500, 2018 01.
Article en En | MEDLINE | ID: mdl-29032316
A trachea is a tubular structure composed of smooth muscle that is reinforced with cartilage rings. Some diseases can cause sagging in smooth muscle and cartilaginous tissue. The end result is reduction (narrowing) of the trachea diameter. A solution to this problem is the use of tracheal stents, which are small tubular devices made of silicone. One is inserted into the trachea to prevent or correct its constriction. The purpose of tracheal stent use is to maintain cartilage support that would otherwise be lost in the airway. Current tracheal stent models present limitations in terms of shape and characteristics of the silicone used in their production. One of the most important is the large thickness of the wall, which makes its placement difficult; this mainly applies to pediatric patients. The wall thickness of the stent is closely related to the mechanical properties of the material. This study aims to test the reinforcement of silicone with three kinds of fibers, and then stents that were produced using fiber with the best compressive strength characteristics. Silicone samples were reinforced with polypropylene (PP), polyamide (PA), and carbon fiber (CF) at concentrations of 2% and 4% (vol%), which then underwent tensile strength and Shore A hardness testing. Samples with fiber showed good characteristics; surface analyses were carried out and they were used to produce stents with an internal diameter of 11 or 13mm and a length of 50mm. Stents underwent compression tests for qualitative evaluation. Samples with 2% and 4% CF blends showed the best mechanical performance, and they were used to produce stents. These samples presented similar compressive strengths at low deformation, but stents with a 4% CF blend exhibited improved compressive strength at deformations greater than 30-50% of their diameter (P ≤ 0.05). The addition of 2% and 4% CF blends conferred greater mechanical strength and resistance to the silicone matrix. This is particularly true at low deformation, which is the condition where the stent is used when implanted. In the finite element compression strength tests, the stent composite showed greater compression strength with the addition of fiber, and the results were in accordance with mechanical compression tests performed on the stents. In vivo tests showed that, after 30 days of post-implantation in sheep trachea, an inflammatory process occurred in the region of the trachea in contact with the stent composite and with the stent without fiber (WF). This response is a common process during the first few days of implantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Siliconas / Tráquea / Materiales Biocompatibles / Bronquios / Stents Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Animals Idioma: En Revista: J Mech Behav Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Siliconas / Tráquea / Materiales Biocompatibles / Bronquios / Stents Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Animals Idioma: En Revista: J Mech Behav Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos