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Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States.
Campbell, Ellsworth M; Jia, Hongwei; Shankar, Anupama; Hanson, Debra; Luo, Wei; Masciotra, Silvina; Owen, S Michele; Oster, Alexandra M; Galang, Romeo R; Spiller, Michael W; Blosser, Sara J; Chapman, Erika; Roseberry, Jeremy C; Gentry, Jessica; Pontones, Pamela; Duwve, Joan; Peyrani, Paula; Kagan, Ron M; Whitcomb, Jeannette M; Peters, Philip J; Heneine, Walid; Brooks, John T; Switzer, William M.
Afiliación
  • Campbell EM; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Jia H; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Shankar A; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Hanson D; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Luo W; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Masciotra S; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Owen SM; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Oster AM; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Galang RR; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Spiller MW; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Blosser SJ; Indiana State Department of Health.
  • Chapman E; Indiana State Department of Health.
  • Roseberry JC; Indiana State Department of Health.
  • Gentry J; Indiana State Department of Health.
  • Pontones P; Indiana State Department of Health.
  • Duwve J; Indiana State Department of Health.
  • Peyrani P; Indiana University Richard M. Fairbanks School of Public Health, Indianapolis.
  • Kagan RM; Division of Infectious Diseases, University of Louisville, Kentucky.
  • Whitcomb JM; Quest Diagnostics, Madison, New Jersey.
  • Peters PJ; LabCorp, Burlington, North Carolina.
  • Heneine W; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Brooks JT; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Switzer WM; Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis ; 216(9): 1053-1062, 2017 11 27.
Article en En | MEDLINE | ID: mdl-29029156
In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a diagnosis of HIV infection. We report results of new approaches to analyzing epidemiologic and laboratory data to understand transmission during this outbreak. HIV genetic distances were calculated using the polymerase region. Networks were generated using data about reported high-risk contacts, viral genetic similarity, and their most parsimonious combinations. Sample collection dates and recency assay results were used to infer dates of infection. Epidemiologic and laboratory data each generated large and dense networks. Integration of these data revealed subgroups with epidemiologic and genetic commonalities, one of which appeared to contain the earliest infections. Predicted infection dates suggest that transmission began in 2011, underwent explosive growth in mid-2014, and slowed after the declaration of a public health emergency. Results from this phylodynamic analysis suggest that the majority of infections had likely already occurred when the investigation began and that early transmission may have been associated with sexual activity and injection drug use. Early and sustained efforts are needed to detect infections and prevent or interrupt rapid transmission within networks of uninfected PWID.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Abuso de Sustancias por Vía Intravenosa / Brotes de Enfermedades / VIH-1 / Alcaloides Opiáceos Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Infect Dis Año: 2017 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Abuso de Sustancias por Vía Intravenosa / Brotes de Enfermedades / VIH-1 / Alcaloides Opiáceos Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Infect Dis Año: 2017 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos