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Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016: a hospital-based test-negative case-control study in Lithuania.
Kuliese, Monika; Jancoriene, Ligita; Grimalauskaite, Rita; Zablockiene, Birute; Damuleviciene, Gyte; Velyvyte, Daiva; Lesauskaite, Vita; Ambrozaitis, Arvydas; Mickiene, Aukse; Gefenaite, Giedre.
Afiliación
  • Kuliese M; Department of Infectious Diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Jancoriene L; Clinic of Infectious, Chest Diseases, Dermatovenerology and Allergology, Vilnius University Faculty of Medicine, Vilnius, Lithuania.
  • Grimalauskaite R; Centre of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
  • Zablockiene B; Department of Geriatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Damuleviciene G; Clinic of Infectious, Chest Diseases, Dermatovenerology and Allergology, Vilnius University Faculty of Medicine, Vilnius, Lithuania.
  • Velyvyte D; Centre of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
  • Lesauskaite V; Department of Geriatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Ambrozaitis A; Department of Infectious Diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Mickiene A; Department of Geriatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Gefenaite G; Clinic of Infectious, Chest Diseases, Dermatovenerology and Allergology, Vilnius University Faculty of Medicine, Vilnius, Lithuania.
BMJ Open ; 7(10): e017835, 2017 Oct 10.
Article en En | MEDLINE | ID: mdl-29018073
OBJECTIVE: A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season. METHODS: A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR) . RESULTS: Ninety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65 years old. Of the 72 (44.2%) influenza virus positive cases, 65 (39.9%) were confirmed with influenza A (including 50 cases of influenza A(H1N1)pdm09), eight (4.9%) were confirmed with influenza B and one was a co-infection. Unadjusted SIVE against any influenza, influenza type A and influenza A(H1N1)pdm09 was 57% (95% CI -41% to 87%), 52% (95% CI -57% to 85%) and 70% (95% CI -43% to 94%) respectively. CONCLUSION: Although SIVE estimates were not statistically significant the point estimates suggest moderate effectiveness against influenza type A.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Estaciones del Año / Vacunas contra la Influenza / Vacunación / Gripe Humana Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged / Pregnancy País/Región como asunto: Europa Idioma: En Revista: BMJ Open Año: 2017 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Estaciones del Año / Vacunas contra la Influenza / Vacunación / Gripe Humana Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged / Pregnancy País/Región como asunto: Europa Idioma: En Revista: BMJ Open Año: 2017 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Reino Unido