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Reduced Severity of Pertussis in Persons With Age-Appropriate Pertussis Vaccination-United States, 2010-2012.
McNamara, Lucy A; Skoff, Tami; Faulkner, Amanda; Miller, Lisa; Kudish, Kathy; Kenyon, Cynthia; Bargsten, Marisa; Zansky, Shelley; Sullivan, Amy D; Martin, Stacey; Briere, Elizabeth.
Afiliación
  • McNamara LA; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Skoff T; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Faulkner A; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Miller L; Colorado Disease Control and Environmental Epidemiology Division, Department of Public Health and Environment, Denver.
  • Kudish K; Connecticut Department of Public Health, Hartford.
  • Kenyon C; Minnesota Department of Health, St Paul.
  • Bargsten M; New Mexico Department of Health, Santa Fe.
  • Zansky S; New York State Department of Health, Albany.
  • Sullivan AD; Communicable Disease Services, Multnomah County Health Department, Portland, Oregon.
  • Martin S; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Briere E; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Clin Infect Dis ; 65(5): 811-818, 2017 Sep 01.
Article en En | MEDLINE | ID: mdl-29017283
BACKGROUND: In 2012, >48000 pertussis cases were reported in the United States. Many cases occurred in vaccinated persons, showing that pertussis vaccination does not prevent all pertussis cases. However, pertussis vaccination may have an impact on disease severity. METHODS: We analyzed data on probable and confirmed pertussis cases reported through Enhanced Pertussis Surveillance (Emerging Infections Program Network) between 2010 and 2012. Surveillance data were collected through physician and patient interview and vaccine registries. We assessed whether having received an age-appropriate number of pertussis vaccines (AAV) (for persons aged ≥3 months) was associated with reduced odds of posttussive vomiting, a marker of more clinically significant illness, or of severe pertussis (seizure, encephalopathy, pneumonia, and/or hospitalization). Adjusted odds ratios were calculated using multivariable logistic regression. RESULTS: Among 9801 pertussis patients aged ≥3 months, 77.6% were AAV. AAV status was associated with a 60% reduction in odds of severe disease in children aged 7 months-6 years in multivariable logistic regression and a 30% reduction in odds of posttussive vomiting in persons aged 19 months-64 years. CONCLUSIONS: Serious pertussis symptoms and complications are less common among AAV pertussis patients, demonstrating that the positive impact of pertussis vaccination extends beyond decreasing risk of disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tos Ferina / Vacunación / Vacunas contra Difteria, Tétanos y Tos Ferina Acelular Tipo de estudio: Etiology_studies / Observational_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tos Ferina / Vacunación / Vacunas contra Difteria, Tétanos y Tos Ferina Acelular Tipo de estudio: Etiology_studies / Observational_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos