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Population-Level Herd Protection of Males From a Female Human Papillomavirus Vaccination Program: Evidence from Australian Serosurveillance.
Pillsbury, Alexis J; Quinn, Helen E; Evans, TaNisha D; McIntyre, Peter B; Brotherton, Julia M L.
Afiliación
  • Pillsbury AJ; National Centre for Immunisation Research and Surveillance, Westmead.
  • Quinn HE; National Centre for Immunisation Research and Surveillance, Westmead.
  • Evans TD; Discipline of Paediatrics and Child Health, University of Sydney, New South Wales, Australia.
  • McIntyre PB; PPD Laboratories, Highland Heights, Kentucky.
  • Brotherton JML; National Centre for Immunisation Research and Surveillance, Westmead.
Clin Infect Dis ; 65(5): 827-832, 2017 Sep 01.
Article en En | MEDLINE | ID: mdl-29017279
BACKGROUND: Australia instituted funded female human papillomavirus (HPV) immunization in 2007, followed by a targeted male vaccination program in 2013. To date, Australia is one of only several countries with a funded male HPV immunization program. In 2012-2013, we conducted a survey of HPV seroprevalence in males to assess whether or not a herd impact of female vaccination could be observed. METHODS: We conducted a cross-sectional study of de-identified residual diagnostic test serum samples from males aged 15-39 years from laboratories in 3 Australian states and calculated the proportion seropositive to HPV types 6, 11, 16, and 18. We compared type-specific results by age group against those from a baseline 2005 Australian HPV serosurvey. RESULTS: There were decreases in proportion seropositive for every HPV type across all age groups, many statistically significant. The largest decrease was observed for HPV-11, with decreases of 8- and 9-fold for ages 20-29 and 30-39 years, respectively. Despite substantial reductions in seroprevalence, at least 9% of males were seropositive for at least 1 of the 4 HPV types. CONCLUSIONS: This is the first serosurvey confirming broad population-level impact in males from female HPV vaccination. Our research may assist policy makers considering implementing HPV vaccination programs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Papillomavirus / Inmunidad Colectiva / Vacunas contra Papillomavirus Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Papillomavirus / Inmunidad Colectiva / Vacunas contra Papillomavirus Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos