Outcomes of organ transplants when the donor is a prior recipient.

Lee, G S; Goldberg, D S; Levine, M H; Abt, P L

Lee, G S; Goldberg, D S; Levine, M H; Abt, P L.

Afiliación

Lee GS; Division of Transplant, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Goldberg DS; Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Levine MH; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Abt PL; Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Am J Transplant ; 18(2): 492-503, 2018 Feb.

Article en En | MEDLINE | ID: mdl-28992380

RESUMEN

Organ shortage continues to challenge the field of transplantation. One potential group of donors are those who have been transplant recipients themselves, or Organ Donation After Transplant (ODAT) donors. We conducted a retrospective cohort study to describe ODAT donors and to compare outcomes of ODAT grafts versus conventional grafts. From October 1, 1987 to June 30, 2015, 517 former recipients successfully donated 803 organs for transplant. Former kidney recipients generally survived a median of approximately 4 years before becoming an ODAT donor whereas liver, lung, and heart recipients generally survived less than a month prior to donation. In the period June 1, 2005 to December 31, 2014, liver grafts from ODAT donors had a significantly higher risk of graft failure compared to non-ODAT liver transplants (P = .008). Kidney grafts donated by ODAT donors whose initial transplant occurred >1 year prior were associated with significantly increased graft failure (P = .012). Despite increased risk of graft failure amongst certain ODAT grafts, 5-year survival was still high. ODAT donors should be considered another form of expanded criteria donor under these circumstances.

Asunto(s)

Supervivencia de Injerto; Donadores Vivos; Trasplante de Órganos/mortalidad; Complicaciones Posoperatorias; Obtención de Tejidos y Órganos/estadística & datos numéricos; Receptores de Trasplantes/estadística & datos numéricos; Adolescente; Adulto; Femenino; Estudios de Seguimiento; Rechazo de Injerto; Humanos; Lactante; Masculino; Persona de Mediana Edad; Pronóstico; Sistema de Registros; Reoperación; Estudios Retrospectivos; Factores de Riesgo; Tasa de Supervivencia; Obtención de Tejidos y Órganos/métodos; Adulto Joven

Palabras clave

clinical research/practice; donors and donation; donors and donation: extended criteria; graft survival; health services and outcomes research; organ acceptance; organ allocation; organ procurement and allocation; organ transplantation in general

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Obtención de Tejidos y Órganos / Trasplante de Órganos / Donadores Vivos / Receptores de Trasplantes / Supervivencia de Injerto Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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