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Clinical outcomes of 125I brachytherapy with and without external-beam radiation therapy for localized prostate cancer: results from 300 patients at a single institution in Japan.
Maki, Sayo; Itoh, Yoshiyuki; Kubota, Seiji; Okada, Tohru; Nakahara, Rie; Ito, Junji; Kawamura, Mariko; Naganawa, Shinji; Yoshino, Yasushi; Fujita, Takashi; Kato, Masashi; Gotoh, Momokazu; Ikeda, Mitsuru.
Afiliación
  • Maki S; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Itoh Y; Radiation and Proton Therapy Center, Nagaizumi, Shizuoka, Japan.
  • Kubota S; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Okada T; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Nakahara R; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Ito J; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Kawamura M; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Naganawa S; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Yoshino Y; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Fujita T; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Kato M; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Gotoh M; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Ikeda M; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
J Radiat Res ; 58(6): 870-880, 2017 Nov 01.
Article en En | MEDLINE | ID: mdl-28992050
The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with 125iodine (125I) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically localized prostate cancer were treated with 125I brachytherapy at the Nagoya University Hospital. A total of 271 men were treated with implants with doses of 145 Gy, and 29 men were treated with implants with doses of 110 Gy combined with EBRT (40-50 Gy/20-25 fractions). The median patient age was 69 years (range, 53-83 years). The median follow-up period was 53 months (range, 5-99 months). According to the National Comprehensive Cancer Network risk classification, 132 men (44%) had low-risk, 147 men (29%) had intermediate-risk and 21 men (7%) had high-risk disease. The 5-year overall survival rate, biochemical relapse-free survival rate, and disease-specific survival rates were 93.5%, 97.3% and 98.5%, respectively. Two men (0.6%) died of prostate cancer and 10 men (3.3%) died of other causes. Seventeen men (5.6%) experienced Grade 2 rectal bleeding in all: 12 (41.4%) of 29 in brachytherapy with EBRT, and 5 (1.8%) of 271 in brachytherapy alone. The rates of Grade 2 and 3 genitourinary toxicity were 1.0% and 1.7%, respectively. Excellent local control was achieved at our hospital for localized prostate cancer with 125I brachytherapy with and without EBRT. Gastrointestinal and genitourinary toxicities were acceptable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Braquiterapia / Radioisótopos de Yodo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Radiat Res Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Braquiterapia / Radioisótopos de Yodo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Radiat Res Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido