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Analysis of bioactive constituents from the leaves of Amorpha fruticosa L.
Cui, Xueqin; Guo, Jing; Lai, Ching-Shu; Pan, Min-Hsiung; Ma, Zhongxiao; Guo, Sen; Liu, Qingchao; Zhang, Li; Ho, Chi-Tang; Bai, Naisheng.
Afiliación
  • Cui X; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Guo J; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Lai CS; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
  • Pan MH; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
  • Ma Z; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Guo S; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Liu Q; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Zhang L; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Ho CT; Department of Food Science, Rutgers University, New Brunswick, NJ, USA.
  • Bai N; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
J Food Drug Anal ; 25(4): 992-999, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28987377
Amorpha fruticosa L. is a Chinese folk medicine and rich in polyphenols. Fifteen known compounds were isolated and identified from the leaves of A. fruticosa L. They are tephrosin (1), 6a,12a-dehydrodeguelin (2), vitexin (3), afrormosin-7-O-ß-d-glucopyranoside (4), 2″-O-α-l-rhamnopyranosyl isovitexin (5), rutin (6), chrysoeriol (7), 7-O-methylluteolin (8), trans-p-coumaric acid (9), 2-benzyl-4,6-dihydroxybenzoic acid-4-O-ß-d-glucopyranoside (10), formononetin (11), quercetin (12), apigenin (13), ß-sitosterol (14), and ß-daucosterol (15). Compounds 3, 4, 5, and 7-9 were isolated from A. fruticosa L. for the first time. Cytotoxicity of individual compounds 3-10 and 90% ethanol extract against human cancer cell lines HCT116 and HepG2 were reported. The results suggested that compounds 7 and 8, and the crude extract exhibited inhibitory effects on human cancer cell line HCT116, at concentrations of 100 µg/mL, 5 µg/mL, and 25 µg/mL at <60% of cell viability rate, respectively. In addition, a valid high-performance liquid chromatography diode array detector method was established to quantitatively analyze compounds 1-12 in the leaves of A. fruticosa L., which was harvested at three different stages of maturity from May 20 to August 10, 2014. The results demonstrated that contents were greatly influenced by the maturity. Total amounts of the analytical constituents gradually increased from May 20 to August 10, with the values ranging from 10.86 mg/g to 18.84 mg/g, whereas bioactive compounds 7 and 8 presented the opposite variation trend. The results of this study may provide data for further study and comprehensive utilization of A. fruticosa L.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Fabaceae Límite: Humans Idioma: En Revista: J Food Drug Anal Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Fabaceae Límite: Humans Idioma: En Revista: J Food Drug Anal Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: China