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Quantitative assessment of the effect of pre-gestational diabetes and risk of adverse maternal, perinatal and neonatal outcomes.
Yu, Lei; Zeng, Xiao-Ling; Cheng, Ming-Liang; Yang, Guo-Zhen; Wang, Bi; Xiao, Zi-Wen; Luo, Xin; Zhang, Bao-Fang; Xiao, De-Wei; Zhang, Shuai; Liu, Hua-Juan; Hu, Ya-Xin; Lei, Hou-Kang; Li, Qin-Fen; Wang, Zheng-Rong.
Afiliación
  • Yu L; Prenatal Diagnosis Center, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Zeng XL; Prenatal Diagnosis Center, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Cheng ML; The First Affiliated Hospital of Jinan University, Guangdong 510632, Guangzhou, China.
  • Yang GZ; Department of Infectious Diseases, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Wang B; Prenatal Diagnosis Center, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Xiao ZW; Prenatal Diagnosis Center, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Luo X; Department of Eugenics and Genetics, Guiyang Maternal and Child Health-Care Hospital, Guiyang 550003, Guizhou, China.
  • Zhang BF; Prenatal Diagnosis Center, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Xiao DW; The First Affiliated Hospital of Jinan University, Guangdong 510632, Guangzhou, China.
  • Zhang S; Department of Infectious Diseases, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Liu HJ; Department of Eugenics and Genetics, Guiyang Maternal and Child Health-Care Hospital, Guiyang 550003, Guizhou, China.
  • Hu YX; Department of Interventional Radiology, Cancer Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Lei HK; Department of Infectious Diseases, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Li QF; Department of Infectious Diseases, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
  • Wang ZR; Prenatal Diagnosis Center, Hospital Affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.
Oncotarget ; 8(37): 61048-61056, 2017 Sep 22.
Article en En | MEDLINE | ID: mdl-28977845
Pregnancies complicated by pre-gestational diabetes (PGD) are associated with a higher rate of adverse outcomes, including an increased rage of preterm delivery, pregnancy-induced hypertension, pre-eclampsia, caesarean section, perinatal mortality, stillbirth, shoulder dystocia, macrosomia, small for gestational age, large for gestational age, low birth weight, neonatal hypoglycemia, neonatal death, low Apgar score, NICU admission, jaundice and respiratory distress. In the past two decades, numerous reports have been published regarding associations between PGD and risk of adverse outcomes. However, study results are inconsistent. To provide a synopsis of the current understanding of PGD for risk of adverse pregnancy outcomes, a random-effects meta-analysis over 40 million subjects from 100 studies was performed to calculate the pooled ORs. Potential sources of heterogeneity were systematically explored by multiple strata analyses and meta-regression. Overall, PGD were significantly associated with increased risk of preterm delivery (OR=3.48), LGA (OR=3.90), perinatal mortality (OR=3.39), stillbirth (OR=3.52), pre-eclampsia (OR=3.48), caesarean section (OR=3.52), NICU admission (OR=3.92), and neonatal hypoglycemia (OR=26.62). Significant results were also observed for 7 adverse outcomes with OR range from 1.54 to 2.82, while no association was found for SGA and respiratory distress after Bonferroni correction. We found that women with T1DM had higher risks for most of adverse pregnancy outcomes compared with women with T2DM. When stratified by study design, sample size, type of diabetes, geographic region, and study quality, significant associations remains. Our findings demonstrated that PGD is a strong risk-conferring factor for adverse maternal, perinatal and neonatal outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos