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Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases.
Sato, Fumi; Maeda, Norikazu; Yamada, Takayuki; Namazui, Hideyuki; Fukuda, Shiro; Natsukawa, Tomoaki; Nagao, Hirofumi; Murai, Jun; Masuda, Shigeki; Tanaka, Yoshimitsu; Obata, Yoshinari; Fujishima, Yuya; Nishizawa, Hitoshi; Funahashi, Tohru; Shimomura, Iichiro.
Afiliación
  • Sato F; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Maeda N; Department of Cardiology, KKR Otemae Hospital.
  • Yamada T; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Namazui H; Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University.
  • Fukuda S; Department of Cardiology, KKR Otemae Hospital.
  • Natsukawa T; Department of Cardiology, KKR Otemae Hospital.
  • Nagao H; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Murai J; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Masuda S; Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital.
  • Tanaka Y; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Obata Y; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Fujishima Y; Department of Internal Medicine, Kawasaki Hospital.
  • Nishizawa H; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Funahashi T; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
  • Shimomura I; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
Circ J ; 82(2): 502-508, 2018 01 25.
Article en En | MEDLINE | ID: mdl-28954947
BACKGROUND: Excess of visceral fat is a central factor in the pathogenesis of metabolic syndrome (MetS) and atherosclerosis. However, little is known about how much epicardial fat affects cardiometabolic disorders in comparison with visceral or subcutaneous fat.Methods and Results:Participants suspected as having angina pectoris underwent cardiac computed tomography (CT) imaging. Of them, 374 subjects were analyzed the association of clinical characteristics and CT-based fat distribution measured as epicardial fat volume (EFV), visceral fat area (VFA), and subcutaneous fat area (SFA). EFV was highly associated with VFA (R=0.58). Serum adiponectin was significantly decreased in high VFA subjects (VFA ≥100 cm2) and was also reduced in the high EFV group (EFV ≥80 cm3). Among the low VFA groups, the numbers of subjects with diabetes and coronary atherosclerosis were increased in high EFV group. Among the low EFV groups, the numbers of subjects with diabetes, hyperuricemia, and coronary atherosclerosis were increased among the high VFA subjects. In an age-, sex-, and body mass index (BMI)-adjusted model, EFV was associated with dyslipidemia and MetS, and VFA was significantly associated with hypertension, dyslipidemia, MetS, and coronary atherosclerosis, while SFA was not related with coronary risks and atherosclerosis. CONCLUSIONS: Epicardial fat accumulation may be a risk for coronary atherosclerosis in subjects without visceral fat accumulation. Visceral fat is the strongest risk for cardiometabolic diseases among the 3 types of fat depot.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pericardio / Enfermedad de la Arteria Coronaria / Grasa Intraabdominal / Grasa Subcutánea / Cardiopatías Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pericardio / Enfermedad de la Arteria Coronaria / Grasa Intraabdominal / Grasa Subcutánea / Cardiopatías Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Japón