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A secreted antibacterial neuropeptide shapes the microbiome of Hydra.
Augustin, René; Schröder, Katja; Murillo Rincón, Andrea P; Fraune, Sebastian; Anton-Erxleben, Friederike; Herbst, Eva-Maria; Wittlieb, Jörg; Schwentner, Martin; Grötzinger, Joachim; Wassenaar, Trudy M; Bosch, Thomas C G.
Afiliación
  • Augustin R; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Schröder K; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Murillo Rincón AP; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Fraune S; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Anton-Erxleben F; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Herbst EM; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Wittlieb J; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Schwentner M; Zoological Institute and Interdisciplinary Research Center Kiel Life Science, University of Kiel, 24098, Kiel, Germany.
  • Grötzinger J; Museum of Comparative Zoology, Harvard University, Cambridge, MA, 02138, USA.
  • Wassenaar TM; Institute of Biochemistry, University of Kiel, 24098, Kiel, Germany.
  • Bosch TCG; Molecular Microbiology and Genomics Consultancy, 55576, Zotzenheim, Germany.
Nat Commun ; 8(1): 698, 2017 09 26.
Article en En | MEDLINE | ID: mdl-28951596
Colonization of body epithelial surfaces with a highly specific microbial community is a fundamental feature of all animals, yet the underlying mechanisms by which these communities are selected and maintained are not well understood. Here, we show that sensory and ganglion neurons in the ectodermal epithelium of the model organism hydra (a member of the animal phylum Cnidaria) secrete neuropeptides with antibacterial activity that may shape the microbiome on the body surface. In particular, a specific neuropeptide, which we call NDA-1, contributes to the reduction of Gram-positive bacteria during early development and thus to a spatial distribution of the main colonizer, the Gram-negative Curvibacter sp., along the body axis. Our findings warrant further research to test whether neuropeptides secreted by nerve cells contribute to the spatial structure of microbial communities in other organisms.Certain neuropeptides, in addition to their neuromodulatory functions, display antibacterial activities of unclear significance. Here, the authors show that a secreted neuropeptide modulates the distribution of bacterial communities on the body surface during development of the model organism Hydra.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuropéptidos / Microbiota / Hydra / Antibacterianos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuropéptidos / Microbiota / Hydra / Antibacterianos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido