Protein backbone flexibility pattern is evolutionarily conserved in the Flaviviridae family: A case of NS3 protease in Flavivirus and Hepacivirus.

Palanisamy, Navaneethan; Akaberi, Dario; Lennerstrand, Johan

Palanisamy, Navaneethan; Akaberi, Dario; Lennerstrand, Johan.

Afiliación

Palanisamy N; Molecular and Cellular Engineering Group, BioQuant, University of Heidelberg, Heidelberg, Germany; The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany. Electronic address: navaneethan.palanisamy@bioquant.uni-heidelberg.de.
Akaberi D; Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Lennerstrand J; Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Mol Phylogenet Evol ; 118: 58-63, 2018 01.

Article en En | MEDLINE | ID: mdl-28951254

RESUMEN

Viruses belonging to the Flaviviridae family have been an important health concern for humans, animals and birds alike. No specific treatment is available yet for many of the viral infections caused by the members of this family. Lack of specific drugs against these viruses is mainly due to lack of protein structure information. It has been known that protein backbone fluctuation pattern is highly conserved in protein pairs with similar folds, in spite of the lack of sequence similarity. We hypothesized that this concept should also hold true for proteins (especially enzymes) of viruses included in different genera of the Flaviviridae family, as we know that the sequence similarity between them is low. Using available NS3 protease crystal structures of the Flaviviridae family, our preliminary results have shown that the Cα (i.e. backbone) fluctuation patterns are highly similar between Flaviviruses and a Hepacivirus (i.e. hepatitis C virus, HCV). This has to be validated further experimentally.

Asunto(s)

Evolución Molecular; Flavivirus/enzimología; Hepacivirus/enzimología; Proteínas no Estructurales Virales/clasificación; Secuencia de Aminoácidos; Animales; Humanos; Funciones de Verosimilitud; Filogenia; Estructura Terciaria de Proteína; ARN Helicasas/química; ARN Helicasas/clasificación; ARN Helicasas/genética; Alineación de Secuencia; Serina Endopeptidasas/química; Serina Endopeptidasas/clasificación; Serina Endopeptidasas/genética; Proteínas no Estructurales Virales/química; Proteínas no Estructurales Virales/genética

Palabras clave

Flaviviridae; Hepatitis C virus (HCV); Protein Cα fluctuation; Viral evolution; Zika virus (ZIKV)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas no Estructurales Virales / Hepacivirus / Evolución Molecular / Flavivirus Límite: Animals / Humans Idioma: En Revista: Mol Phylogenet Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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