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Differential regulation of Effector and Regulatory T cell function by Blimp1.
Bankoti, Rashmi; Ogawa, Chihiro; Nguyen, Truc; Emadi, Lena; Couse, Michael; Salehi, Soofia; Fan, Xuemo; Dhall, Deepti; Wang, Yizhou; Brown, Jordan; Funari, Vincent; Tang, Jie; Martins, Gislâine A.
Afiliación
  • Bankoti R; Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI), Los Angeles, CA, USA.
  • Ogawa C; Biomedical Sciences, Research Division of Immunology, CSMC, Los Angeles, CA, USA.
  • Nguyen T; Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI), Los Angeles, CA, USA.
  • Emadi L; Biomedical Sciences, Research Division of Immunology, CSMC, Los Angeles, CA, USA.
  • Couse M; Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI), Los Angeles, CA, USA.
  • Salehi S; Fluidigm, South San Francisco, CA, USA.
  • Fan X; Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI), Los Angeles, CA, USA.
  • Dhall D; Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI), Los Angeles, CA, USA.
  • Wang Y; Dept of Pathology, Los Angeles, CA, USA.
  • Brown J; Dept of Pathology, Los Angeles, CA, USA.
  • Funari V; Genomics Core, Cedars-Sinai Medical Center (CSMC), Los Angeles, CA, USA.
  • Tang J; Biomedical Sciences, Research Division of Immunology, CSMC, Los Angeles, CA, USA.
  • Martins GA; Genomics Core, Cedars-Sinai Medical Center (CSMC), Los Angeles, CA, USA.
Sci Rep ; 7(1): 12078, 2017 09 21.
Article en En | MEDLINE | ID: mdl-28935958
The transcriptional regulator Blimp1 plays crucial roles in controlling terminal differentiation in several lineages. In T cells, Blimp1 is expressed in both effector (Teff) and regulatory (Treg) cells, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spontaneously develop severe intestinal inflammation, indicating a crucial role for Blimp1 in T cell homeostasis regulation. Blimp1 has been shown to function as a direct activator of the Il10 gene and although its requirement for IL10 expression has been demonstrated in both Treg and Teff cells under inflammatory conditions, the intrinsic requirement of Blimp1 for homeostatic maintenance of these T cell subsets had not been investigated. Using mice with Foxp3+ Treg-cell specific deletion of Blimp1 and other approaches, here we show that Foxp3+ Treg cell-intrinsic expression of Blimp1 is required to control Treg and Teff cells homeostasis but, unexpectedly, it is dispensable to prevent development of severe spontaneous intestinal inflammation. In addition, we show that Blimp1 controls common and unique aspects of Treg and Teff cell function by differentially regulating gene expression in these T cell subsets. These findings document previously unappreciated aspects of Blimp1's role in T cell biology and shed light on the intricate mechanisms regulating Treg and Teff cell function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Perfilación de la Expresión Génica / Factor 1 de Unión al Dominio 1 de Regulación Positiva / Homeostasis Límite: Animals Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Perfilación de la Expresión Génica / Factor 1 de Unión al Dominio 1 de Regulación Positiva / Homeostasis Límite: Animals Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido