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Evaluation of familial factors in a Mexican population-based setting with gastroschisis: Further evidence for an underlying genetic susceptibility.
Salinas-Torres, Victor M; Salinas-Torres, Rafael A; Cerda-Flores, Ricardo M; Martínez-de-Villarreal, Laura E.
Afiliación
  • Salinas-Torres VM; Universidad Autónoma de Nuevo León, Departamento de Genética, Facultad de Medicina y Hospital Universitario José Eleuterio González, Ave. Madero y Gonzalitos S/N Col. Mitras Centro, Monterrey, Nuevo León CP 64460, Mexico.; Instituto de Servicios de Salud Pública en el Estado de Baja California, Depa
  • Salinas-Torres RA; Instituto de Servicios de Salud Pública en el Estado de Baja California, Departamento de Genética, Hospital General Tijuana, Av Centenario 10851, Zona Rio, Tijuana, Baja California CP 22320, Mexico.; Instituto Tecnológico de Tijuana, Departamento de Sistemas y Computación, Calzada del Tecnológico S/
  • Cerda-Flores RM; Universidad Autónoma de Nuevo León, Facultad de Enfermería, Dr. José Eleuterio González 1500, Mitras Norte, Monterrey, Nuevo León CP 64460, Mexico.. Electronic address: ricardocerda_mx@yahoo.com.mx.
  • Martínez-de-Villarreal LE; Universidad Autónoma de Nuevo León, Departamento de Genética, Facultad de Medicina y Hospital Universitario José Eleuterio González, Ave. Madero y Gonzalitos S/N Col. Mitras Centro, Monterrey, Nuevo León CP 64460, Mexico.. Electronic address: laelmar@yahoo.com.mx.
J Pediatr Surg ; 53(3): 521-524, 2018 Mar.
Article en En | MEDLINE | ID: mdl-28935396
PURPOSE: To evaluate the occurrence of gastroschisis attributable to familial factors in a Mexican population-based setting. METHODS: A descriptive study was performed among gastroschisis cases born from 2010 through 2016 at Tijuana General Hospital (Baja California, Mexico) to generate multigenerational pedigrees. RESULTS: There were 87 gastroschisis cases from 57,217 live births. Six probands (6.9%) had another affected family member. Two half-siblings, a set of monozygotic twins, a mother-and-daughter occurrence, a distant paternal cousin and a distant maternal uncle were identified. Sibling recurrence was 5.5%. From 174 males and 153 females studied (n=327, involving 180 nuclear families), sex-dependent influence analysis evidenced an increased susceptibility to gastroschisis in males (3.2%) compared to females (1.8%) with an overall of 2.5% adjusted for proband. CONCLUSIONS: Our results provide a greater liability attributable to familial factors on gastroschisis. In spite of the predominant sporadic occurrence, underlying genetic susceptibility and environmental influences point to a complex interplay between genes and environmental factors in gastroschisis. LEVEL OF EVIDENCE: Level IV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gastrosquisis / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Pregnancy País/Región como asunto: Mexico Idioma: En Revista: J Pediatr Surg Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gastrosquisis / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Pregnancy País/Región como asunto: Mexico Idioma: En Revista: J Pediatr Surg Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos