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Cigarette Smoking is Associated with Decreased Bone Gla-protein (BGP) Levels in Hemodialysis Patients.
Fusaro, Maria; Gallieni, Maurizio; Aghi, Andrea; Iervasi, Giorgio; Rizzo, Maria A; Stucchi, Andrea; Noale, Marianna; Tripepi, Giovanni; Nickolas, Thomas; Veronese, Nicola; Fabris, Fabrizio; Giannini, Sandro; Calo, Lorenzo; Piccoli, Antonio; Mereu, Maria C; Cosmai, Laura; Ferraro, Alberto; Magonara, Fiorenza; Spinello, Michela; Sella, Stefania; Plebani, Mario.
Afiliación
  • Fusaro M; National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa Via G. Moruzzi 1, 56124, Pisa, PI, Italy.
  • Gallieni M; Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, PD, Italy.
  • Aghi A; Department of Clinical and Biomedical Sciences "Luigi Sacco", Nephrology and Dialysis Unit, Ospedale San Carlo Borromeo, University of Milan, Milan, Italy.
  • Iervasi G; Department of Medicine, Clinica Medica 1, University of Padova, Padova, Italy.
  • Rizzo MA; National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa Via G. Moruzzi 1, 56124, Pisa, PI, Italy.
  • Stucchi A; Nephrology and Dialysis Unit, Ospedale di Circolo di Busto Arsizio, ASST Valle Olona, Italy.
  • Noale M; Nephrology and Dialysis Unit, IRCCS Multimedica, Sesto San Giovanni (Milano), Milan, Italy.
  • Tripepi G; National Research Council (CNR), Neuroscience Institute, Padua, Italy.
  • Nickolas T; Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, CNR, Institute of Biomedicine, Reggio Calabria, Calabria, Italy.
  • Veronese N; Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, United States.
  • Fabris F; Department of Medicine (DI-MED), Geriatric Section, University of Padua, Italy.
  • Giannini S; Department of Medicine, Clinica Medica 1, University of Padova, Padova, Italy.
  • Calo L; Department of Medicine, Clinica Medica 1, University of Padova, Padova, Italy.
  • Piccoli A; Nephrology Unit, University of Padua, Padua, Italy.
  • Mereu MC; Nephrology Unit, University of Padua, Padua, Italy.
  • Cosmai L; Ospedale N.S. di Bonaria, San Gavino Monreale, Italy.
  • Ferraro A; Istituti Ospitalieri di Cremona, Cremona, Italy.
  • Magonara F; Unita di Nefrologia di Castelfranco Veneto, Treviso, Italy.
  • Spinello M; Unita di Nefrologia e Dialisi, Ospedale Alto Vicentino Santorso, Vicenza, Italy.
  • Sella S; Unita di Nefrologia-Emodialisi O.C. Piove di Sacco Ulss 6, Padova, Italy.
  • Plebani M; Department of Medicine, Clinica Medica 1, University of Padova, Padova, Italy.
Curr Vasc Pharmacol ; 16(6): 603-609, 2018.
Article en En | MEDLINE | ID: mdl-28933309
BACKGROUND: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. METHODS: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. RESULTS: Smokers had significantly lower BGP levels (152 vs. 204 µg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). CONCLUSION: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteocalcina / Diálisis Renal / Fumar Cigarrillos / Fumadores / Fallo Renal Crónico Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Curr Vasc Pharmacol Asunto de la revista: ANGIOLOGIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Emiratos Árabes Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteocalcina / Diálisis Renal / Fumar Cigarrillos / Fumadores / Fallo Renal Crónico Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Curr Vasc Pharmacol Asunto de la revista: ANGIOLOGIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Emiratos Árabes Unidos