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The efficacy of a working memory training in substance use patients: A randomized double-blind placebo-controlled clinical trial.
Wanmaker, Sabine; Leijdesdorff, Sophie Maaike Jorinde; Geraerts, Elke; van de Wetering, Ben J M; Renkema, Peter J; Franken, Ingmar H A.
Afiliación
  • Wanmaker S; a Institute of Psychology , Erasmus University Rotterdam , Rotterdam , the Netherlands.
  • Leijdesdorff SMJ; b Department of Neurology , Erasmus Medical Center , Rotterdam , The Netherlands.
  • Geraerts E; a Institute of Psychology , Erasmus University Rotterdam , Rotterdam , the Netherlands.
  • van de Wetering BJM; c Bouman Mental Health Care , Rotterdam , the Netherlands.
  • Renkema PJ; a Institute of Psychology , Erasmus University Rotterdam , Rotterdam , the Netherlands.
  • Franken IHA; a Institute of Psychology , Erasmus University Rotterdam , Rotterdam , the Netherlands.
J Clin Exp Neuropsychol ; 40(5): 473-486, 2018 06.
Article en En | MEDLINE | ID: mdl-28933254
INTRODUCTION: Substance use disorder patients show impairments in working memory (WM) functioning. Previous findings indicate that a WM training results in improvements of working memory capacity (WMC) and in decreased clinical symptoms in a range of mental disorders, including alcohol use disorder. METHOD: The aim of the current study is to investigate the efficacy of a 24-session WM training in addition to treatment as usual on craving, WMC, substance use, impulsivity, attention bias, and psychopathology using a randomized double-blind placebo-controlled trial. Inpatients (n = 180) diagnosed with an alcohol, cocaine, or cannabis use disorder were included. RESULTS: Although the WM training resulted in better scores on the trained tasks in both groups, the placebo training resulted in a better or equal WMC compared to the experimental training, as measured with two nontrained transfer tasks. The WM training had no effect on craving, substance use, impulsivity, attention bias, and psychopathology. CONCLUSION: Overall, we did not find evidence for the efficacy of WM training on WMC or clinical symptoms as compared to a placebo training in a population of substance use disorder patients. Future research needs to investigate further whether WMC is an important factor that is associated with substance-abuse-related behavior, and whether working memory training could be useful in substance use disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Relacionados con Sustancias / Aprendizaje / Memoria a Corto Plazo Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Exp Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Relacionados con Sustancias / Aprendizaje / Memoria a Corto Plazo Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Exp Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido