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Primary pulmonary malignant fibrous histiocytoma: case report and literature review.
Li, Xiongfei; Liu, Renwang; Shi, Tao; Dong, Shangwen; Ren, Fan; Yang, Fan; Ren, Dian; Fan, Haiyang; Wei, Sen; Chen, Gang; Chen, Jun; Xu, Song.
Afiliación
  • Li X; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Liu R; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Shi T; Department of Pathology, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Dong S; Department of Cardiothoracic Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Ren F; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Yang F; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Ren D; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Fan H; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Wei S; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Chen G; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Chen J; Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Xu S; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
J Thorac Dis ; 9(8): E702-E708, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28932590
Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five gene mutations in TSC2, ARID1B, CDK8, KDM5C and CASP8 were detected, and the mTOR inhibitor might be an effective treatment for this patient. In addition, we reviewed the scientific literature of approximately 23 primary pulmonary MFH case reports since 1990 and summarized the clinical features and prognosis of this rare pulmonary malignant tumor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Thorac Dis Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Thorac Dis Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: China