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3-Bromo-4,5-dihydroxybenzaldehyde Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes.
Kim, Ki Cheon; Hyun, Yu Jae; Hewage, Susara Ruwan Kumara Madduma; Piao, Mei Jing; Kang, Kyoung Ah; Kang, Hee Kyoung; Koh, Young Sang; Ahn, Mee Jung; Hyun, Jin Won.
Afiliación
  • Kim KC; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. svv771@hotmail.com.
  • Hyun YJ; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. yujae_1113@naver.com.
  • Hewage SRKM; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. susaramh@gmail.com.
  • Piao MJ; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. meijing0219@hotmail.com.
  • Kang KA; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. legna07@naver.com.
  • Kang HK; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. pharmkhk@jejunu.ac.kr.
  • Koh YS; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. yskoh7@jejunu.ac.kr.
  • Ahn MJ; Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. healthy@jejunu.ac.kr.
  • Hyun JW; Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Korea. jinwonh@jejunu.ac.kr.
Mar Drugs ; 15(9)2017 Sep 18.
Article en En | MEDLINE | ID: mdl-28926995
A natural bromophenol found in seaweeds, 3-bromo-4,5-dihydroxybenzaldehyde (BDB), has been shown to possess antioxidant effects. This study aimed to investigate the mechanism by which BDB protects skin cells subjected to oxidative stress. The effect of BDB on the protein and mRNA levels of glutathione-related enzymes and the cell survival of human keratinocytes (HaCaT cells) was investigated. BDB treatment increased the protein and mRNA levels of glutathione synthesizing enzymes and enhanced the production of reduced glutathione in HaCaT cells. Furthermore, BDB activated NF-E2-related factor 2 (Nrf2) and promoted its localization into the nucleus by phosphorylating its up-stream signaling proteins, extracellular signal-regulated kinase and protein kinase B. Thus, BDB increased the production of reduced glutathione and established cellular protection against oxidative stress via an Nrf2-mediated pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Benzaldehídos / Queratinocitos / Factor 2 Relacionado con NF-E2 / Glutatión / Antioxidantes Límite: Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Benzaldehídos / Queratinocitos / Factor 2 Relacionado con NF-E2 / Glutatión / Antioxidantes Límite: Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Suiza