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Characterization of Intracellular Activity of Antitubercular Constituents the Roots of Euclea natalensis.
Lall, N; Meyer, J J Marion; Wang, Y; Bapela, N B; van Rensburg, C E J; Fourie, B; Franzblau, S G.
Afiliación
  • Lall N; a Department of Botany, University of Pretoria, Pretoria, South Africa.
  • Meyer JJM; a Department of Botany, University of Pretoria, Pretoria, South Africa.
  • Wang Y; b Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
  • Bapela NB; c Department of Pharmacology, University of Pretoria, Pretoria, South Africa.
  • van Rensburg CEJ; c Department of Pharmacology, University of Pretoria, Pretoria, South Africa.
  • Fourie B; d Medical Research Council of South Africa, TB Research Lead Programme, Pretoria, South Africa.
  • Franzblau SG; b Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
Pharm Biol ; 43(4): 353-357, 2005.
Article en En | MEDLINE | ID: mdl-28925832
Naphthoquinones and triterpenes isolated from the roots of Euclea natalensis. A.DC (Ebenaceae) were evaluated for their inhibitory activity against Mycobacterium tuberculosis.. Crude extract, diospyrin and 7-methyljuglone isolated from the plant, exhibited minimum inhibitory concentrations of 8.0, 8.0, and 0.5 µg ml-1, respectively, against M. tuberculosis. H37 Rv (ATCC 27294), a drug-sensitive strain. Minimum inhibitory concentrations (MICs) of 7- methyljuglone against a panel of clinical pan-sensitive and drug-resistant strains of M. tuberculosis. ranged from 0.32 to 1.25 µg/ml. The concentration of 7-methyljuglone that effected a 90% reduction of growth of M. tuberculosis. Erdman within J774.1 macrophages was 0.57 µg/ml. The superior intracellular and extracellular inhibition of M. tuberculosis. by 7-methyljuglone relative to that of the antituberculosis drugs streptomycin and ethambutol suggests that this compound be considered as a lead for further investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharm Biol Año: 2005 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharm Biol Año: 2005 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido