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Chemical crosslinking of biopolymeric scaffolds: Current knowledge and future directions of crosslinked engineered bone scaffolds.
Oryan, Ahmad; Kamali, Amir; Moshiri, Ali; Baharvand, Hossien; Daemi, Hamed.
Afiliación
  • Oryan A; Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
  • Kamali A; Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran; Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
  • Moshiri A; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Baharvand H; Department of Developmental Biology, University of Science and Culture, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
  • Daemi H; Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: H.Daemi@royaninstitute.org.
Int J Biol Macromol ; 107(Pt A): 678-688, 2018 Feb.
Article en En | MEDLINE | ID: mdl-28919526
Bone tissue scaffolds made from either natural or synthetic polymers are employed to promote bone healing. However, lack of sufficient or poor mechanical properties such as low integrity and stability reduces their medical applications. Crosslinking, defined as induction of chemical or physical links among polymer chains, is a simple method generally used to modify mechanical, biological and degradation properties of hydrogels. Although crosslinking through chemical reactions improves the mechanical properties of bone substitutes, most of the reagents used for this aim demonstrate undesirable effects and may exert toxic reactions. Glutaraldehyde is a widely-used chemical crosslinker with unique ability to crosslink a wide variety of biomaterials; however, many contradictory views have been recently raised on its cytotoxic effects. By keeping this limit in mind, green chemicals or natural crosslinking agents have been shown to provide desired improvements in mechanical properties of bone scaffolds. Therefore, developing more efficient crosslinking materials and methods are desirable to obtain crosslinked scaffolds with perfect properties in bone tissue engineering from different biopolymers such as collagen, gelatin, cellulose, chitosan, alginate, etc. In this review, we focused on developed or developing modalities used to improve mechanical properties of various bone scaffolds and matrices based on common crosslinking reagents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Ácido Cítrico / Reactivos de Enlaces Cruzados / Iridoides / Andamios del Tejido / Glioxal Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Ácido Cítrico / Reactivos de Enlaces Cruzados / Iridoides / Andamios del Tejido / Glioxal Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos