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Zbtb1 controls NKp46+ ROR-gamma-T+ innate lymphoid cell (ILC3) development.
Lu, Ying; Zhang, Xianyu; Bouladoux, Nicolas; Kaul, Saransh Neel; Jin, Kangxin; Sant'Angelo, Derek; Belkaid, Yasmine; Kovalovsky, Damian.
Afiliación
  • Lu Y; Experimental Immunology Branch, NCI, NIH, Bethesda, MD, USA.
  • Zhang X; Experimental Immunology Branch, NCI, NIH, Bethesda, MD, USA.
  • Bouladoux N; Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.
  • Kaul SN; University of Maryland, College Park, MD, USA.
  • Jin K; Zhongshan Ophthalmic Center, State Key Laboratory for Ophthalmic Researches, Sun Yat-Sen University, Guangzhou, Guangdong, China.
  • Sant'Angelo D; Cancer Metabolism and Growth Program, Rutgers, Child Health Institute of New Jersey, New Brunswick, NJ, USA.
  • Belkaid Y; Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.
  • Kovalovsky D; Experimental Immunology Branch, NCI, NIH, Bethesda, MD, USA.
Oncotarget ; 8(34): 55877-55888, 2017 Aug 22.
Article en En | MEDLINE | ID: mdl-28915559
Innate lymphoid cells (ILCs) play a central role conferring protection at the mucosal frontier. In this study, we have identified a requirement of the transcription factor Zbtb1 for the development of RORγt+ ILCs (ILC3s). Zbtb1-deficient mice lacked NKp46+ ILC3 cells in the lamina propria of the small and large intestine. This requirement of Zbtb1 was cell intrinsic, as NKp46+ ILC3s were not generated from Zbtb1-deficient progenitors in bone marrow chimeras and Zbtb1-deficient RORγt+ CCR6-NKp46- ILC3s didn't generate NKp46+ ILC3s in co-cultures with OP9-DL1 stroma. In correlation with this impairment, Zbtb1-deficient ILC3 cells failed to upregulate T-bet expression, and to acquire IFN-γ production characteristic of NKp46+ cells. Finally, absence of NKp46+ILC3 cells combined with the absence of T-cells in Zbtb1-deficient mice, led to a transient susceptibility to C. rodentium infections. Altogether, these results establish that Zbtb1 is essential for the development of NKp46+ ILC3 cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos