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Cytogenetic analysis in fetuses with late onset abnormal sonographic findings.
Bardin, Ron; Hadar, Eran; Haizler-Cohen, Lylach; Gabbay-Benziv, Rinat; Meizner, Israel; Kahana, Sarit; Yeshaya, Josepha; Yacobson, Shiri; Cohen-Vig, Lital; Agmon-Fishman, Ifaat; Basel-Vanagaite, Lina; Maya, Idit.
Afiliación
  • Bardin R; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Hadar E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Haizler-Cohen L; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Gabbay-Benziv R; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Meizner I; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Kahana S; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Yeshaya J; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Yacobson S; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Cohen-Vig L; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Agmon-Fishman I; Raphael Recanati Genetic Institute, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Basel-Vanagaite L; Raphael Recanati Genetic Institute, Rabin Medical Center, Petah Tikva 49100, Israel.
  • Maya I; Raphael Recanati Genetic Institute, Rabin Medical Center, Petah Tikva 49100, Israel.
J Perinat Med ; 46(9): 975-982, 2018 Nov 27.
Article en En | MEDLINE | ID: mdl-28915119
OBJECTIVE: To determine the rate of chromosomal cytogenetic abnormalities in fetuses with late onset abnormal sonographic findings. DESIGN: Retrospective cohort of women who underwent amniocentesis at or beyond 23 weeks of gestation, for fetal karyotype and chromosomal microarray analysis, indicated due to late onset abnormal sonographic findings. RESULTS: All 103 fetuses had a normal karyotype. Ninety-five women also had chromosomal microarray analysis (CMA) performed. The detection rate of abnormal CMA (5/95, 5.3%) was similar to that of women who underwent amniocentesis due to abnormal early onset ultrasound findings detected at routine prenatal screening tests during the first or early second trimester (7.3%, P=0.46) and significantly higher than that for women who underwent amniocentesis and CMA upon request, without a medical indication for CMA (0.99%, P<0.0001). CONCLUSIONS: Late onset sonographic findings are an indication for amniocentesis, and if performed, CMA should be applied to evaluate fetuses with late onset abnormal sonographic findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aberraciones Cromosómicas / Trastornos de los Cromosomas / Análisis Citogenético Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: J Perinat Med Año: 2018 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aberraciones Cromosómicas / Trastornos de los Cromosomas / Análisis Citogenético Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: J Perinat Med Año: 2018 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Alemania