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Power frequency magnetic field promotes a more malignant phenotype in neuroblastoma cells via redox-related mechanisms.
Falone, S; Santini, S; Cordone, V; Cesare, P; Bonfigli, A; Grannonico, M; Di Emidio, G; Tatone, C; Cacchio, M; Amicarelli, F.
Afiliación
  • Falone S; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. stefano.falone@univaq.it.
  • Santini S; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Cordone V; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Cesare P; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Bonfigli A; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Grannonico M; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Di Emidio G; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Tatone C; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Cacchio M; Department of Neurosciences, Imaging and Clinical Sciences, University "G. d'Annunzio", Chieti Scalo (CH), Italy.
  • Amicarelli F; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Sci Rep ; 7(1): 11470, 2017 09 13.
Article en En | MEDLINE | ID: mdl-28904402
In accordance with the classification of the International Agency for Research on Cancer, extremely low frequency magnetic fields (ELF-MF) are suspected to promote malignant progression by providing survival advantage to cancer cells through the activation of critical cytoprotective pathways. Among these, the major antioxidative and detoxification defence systems might be targeted by ELF-MF by conferring cells significant resistance against clinically-relevant cytotoxic agents. We investigated whether the hyperproliferation that is induced in SH-SY5Y human neuroblastoma cells by a 50 Hz, 1 mT ELF magnetic field was supported by improved defence towards reactive oxygen species (ROS) and xenobiotics, as well as by reduced vulnerability against both H2O2 and anti-tumor ROS-generating drug doxorubicin. ELF-MF induced a proliferative and survival advantage by activating key redox-responsive antioxidative and detoxification cytoprotective pathways that are associated with a more aggressive behavior of neuroblastoma cells. This was coupled with the upregulation of the major sirtuins, as well as with increased signaling activity of the erythroid 2-related nuclear transcription factor 2 (NRF2). Interestingly, we also showed that the exposure to 50 Hz MF as low as 100 µT may still be able to alter behavior and responses of cancer cells to clinically-relevant drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Campos Magnéticos / Neuroblastoma Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Campos Magnéticos / Neuroblastoma Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido