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Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy.
Ding, Xiao-Xiao; Zhu, Qing-Ge; Zhang, Shi-Ming; Guan, Lei; Li, Ting; Zhang, Lei; Wang, Shi-Yang; Ren, Wan-Li; Chen, Xue-Mei; Zhao, Jing; Lin, Song; Liu, Zhi-Zhen; Bai, Yan-Xia; He, Bing; Zhang, Hu-Qin.
Afiliación
  • Ding XX; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Zhu QG; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Zhang SM; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Guan L; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Li T; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Zhang L; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Wang SY; Department of Otorhinolaryngology - Head and Neck Surgery, The First Affiliated Hospital, Jiaotong University, Shaanxi 710061, P. R. China.
  • Ren WL; Department of Otorhinolaryngology - Head and Neck Surgery, The First Affiliated Hospital, Jiaotong University, Shaanxi 710061, P. R. China.
  • Chen XM; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Zhao J; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Lin S; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Liu ZZ; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Bai YX; Department of Otorhinolaryngology - Head and Neck Surgery, The First Affiliated Hospital, Jiaotong University, Shaanxi 710061, P. R. China.
  • He B; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Zhang HQ; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Oncotarget ; 8(33): 55715-55730, 2017 Aug 15.
Article en En | MEDLINE | ID: mdl-28903454
Hepatocellular carcinoma (HCC) is the third most frequent cause of tumor-related mortality and there are an estimated approximately 850,000 new cases annually. Most HCC patients are diagnosed at middle or advanced stage, losing the opportunity of surgery. The development of HCC is promoted by accumulated diverse genetic mutations, which confer selective growth advantages to tumor cells and are called "driver mutations". The discovery of driver mutations provides a novel precision medicine strategy for late stage HCC, called targeted therapy. In this review, we summarized currently discovered driver mutations and corresponding signaling pathways, made an overview of identification methods of driver mutations and genes, and classified targeted drugs for HCC. The knowledge of mutational landscape deepen our understanding of carcinogenesis and promise future precision medicine for HCC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos