Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

Pai, Chen-Chun; Kishkevich, Anastasiya; Deegan, Rachel S; Keszthelyi, Andrea; Folkes, Lisa; Kearsey, Stephen E; De León, Nagore; Soriano, Ignacio; de Bruin, Robertus Antonius Maria; Carr, Antony M; Humphrey, Timothy C

Pai, Chen-Chun; Kishkevich, Anastasiya; Deegan, Rachel S; Keszthelyi, Andrea; Folkes, Lisa; Kearsey, Stephen E; De León, Nagore; Soriano, Ignacio; de Bruin, Robertus Antonius Maria; Carr, Antony M; Humphrey, Timothy C.

Afiliación

Pai CC; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address: chen-chun.pai@oncology.ox.ac.uk.
Kishkevich A; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6B, UK.
Deegan RS; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Keszthelyi A; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex BN1 9RQ, UK.
Folkes L; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Kearsey SE; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
De León N; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
Soriano I; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
de Bruin RAM; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6B, UK.
Carr AM; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex BN1 9RQ, UK.
Humphrey TC; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address: timothy.humphrey@oncology.ox.ac.uk.

Cell Rep ; 20(11): 2693-2705, 2017 Sep 12.

Article en En | MEDLINE | ID: mdl-28903048

Asunto(s)

Proteínas de Ciclo Celular/metabolismo; Daño del ADN; Replicación del ADN; N-Metiltransferasa de Histona-Lisina/metabolismo; Proteínas de Schizosaccharomyces pombe/metabolismo; Schizosaccharomyces/enzimología; Schizosaccharomyces/genética; Factores de Transcripción/metabolismo; Transcripción Genética; Puntos de Control del Ciclo Celular/genética; Daño del ADN/genética; Replicación del ADN/genética; ADN de Hongos/metabolismo; Regulación hacia Abajo/genética; Regulación Fúngica de la Expresión Génica; Genes Fúngicos; Mutación/genética; Nucleótidos/metabolismo; Origen de Réplica/genética; Fase S/genética

Palabras clave

DNA replication; MBF; Schizosaccharomyces pombe; Set2; dNTP; histone H3K36 methylation; histone methylation; ribonucleotide reductase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Schizosaccharomyces / Factores de Transcripción / Transcripción Genética / Daño del ADN / N-Metiltransferasa de Histona-Lisina / Proteínas de Ciclo Celular / Proteínas de Schizosaccharomyces pombe / Replicación del ADN Idioma: En Revista: Cell Rep Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos

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