[Research advances in pharmacogenomics of mercaptopurine].
Zhongguo Dang Dai Er Ke Za Zhi
; 19(9): 1027-1033, 2017 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-28899477
Mercaptopurine is a common chemotherapeutic drug and immunosuppressive agent and plays an important role in the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. It may cause severe adverse effects such as myelosuppression, which may result in the interruption of treatment or complications including infection or even threaten patients' lives. However, the adverse effects of mercaptopurine show significant racial and individual differences, which reveal the important role of genetic diversity. Recent research advances in pharmacogenomics have gradually revealed the genetic nature of such differences. This article reviews the recent research advances in the pharmacogenomics and individualized application of mercaptopurine.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Mercaptopurina
/
Antimetabolitos Antineoplásicos
Límite:
Humans
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2017
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China