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Endothelial cells maintain neural stem cells quiescent in their niche.
Azevedo, Patrick O; Lousado, Luiza; Paiva, Ana E; Andreotti, Julia P; Santos, Gabryella S P; Sena, Isadora F G; Prazeres, Pedro H D M; Filev, Renato; Mintz, Akiva; Birbrair, Alexander.
Afiliación
  • Azevedo PO; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Lousado L; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Paiva AE; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Andreotti JP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Santos GSP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Sena IFG; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Prazeres PHDM; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Filev R; Laboratory of Neurobiology, Federal University of São Paulo, SP, Brazil.
  • Mintz A; Department of Radiology, Columbia University Medical Center, New York, NY, USA.
  • Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Br
Neuroscience ; 363: 62-65, 2017 11 05.
Article en En | MEDLINE | ID: mdl-28893649
Niches are specialized microenvironments that regulate stem cells' activity. The neural stem cell (NSC) niche defines a zone in which NSCs are retained and produce new cells of the nervous system throughout life. Understanding the signaling mechanisms by which the niche controls the NSC fate is crucial for the success of clinical applications. In a recent study, Sato and colleagues, by using state-of-the-art techniques, including sophisticated in vivo lineage-tracing technologies, provide evidence that endothelial amyloid precursor protein (APP) is an important component of the NSC niche. Strikingly, depletion of APP increased NSC proliferation in the subventricular zone, indicating that endothelial cells negatively regulate NSCs' growth. The emerging knowledge from this research will be important for the treatment of several neurological diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Adultas / Células-Madre Neurales Límite: Adult / Humans Idioma: En Revista: Neuroscience Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Adultas / Células-Madre Neurales Límite: Adult / Humans Idioma: En Revista: Neuroscience Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos