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The impact of repeated mismatches in kidney transplantations performed after nonrenal solid organ transplantation.
Côté, J M; Zhang, X; Dahhou, M; Sapir-Pichhadze, R; Foster, B; Cardinal, H.
Afiliación
  • Côté JM; Research centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
  • Zhang X; Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
  • Dahhou M; Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
  • Sapir-Pichhadze R; McGill University Health Center, Montreal, QC, Canada.
  • Foster B; Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
  • Cardinal H; Research centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Am J Transplant ; 18(1): 238-244, 2018 01.
Article en En | MEDLINE | ID: mdl-28891113
The aim of this study was to determine whether kidney transplantations performed after previous nonrenal solid organ transplants are associated with worse graft survival when there are repeated HLA mismatches (RMM) with the previous donor(s). We performed a retrospective cohort study using data from the Scientific Registry of Transplant Recipients. Our cohort comprised 6624 kidney transplantations performed between January 1, 1990 and January 1, 2015. All patients had previously received 1 or more nonrenal solid organ transplants. RMM were observed in 35.3% of kidney transplantations and 3012 grafts were lost over a median follow-up of 5.4 years. In multivariate Cox regression analyses, we found no association between overall graft survival and either RMM in class 1 (hazard ratio [HR]: 0.97, 95% confidence interval [CI] 0.89-1.07) or class 2 (HR: 0.95, 95% CI 0.85-1.06). Results were similar for the associations between RMM, death-censored graft survival, and patient survival. Our results suggest that the presence of RMM with previous donor(s) does not have an important impact on allograft survival in kidney transplant recipients who have previously received a nonrenal solid organ transplant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Trasplante de Riñón / Rechazo de Injerto / Histocompatibilidad / Fallo Renal Crónico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Trasplante de Riñón / Rechazo de Injerto / Histocompatibilidad / Fallo Renal Crónico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos