Your browser doesn't support javascript.
loading
Medicinal plants for in vitro antiplasmodial activities: A systematic review of literature.
Lemma, Martha Tibebu; Ahmed, Ali Mahmoud; Elhady, Mohamed Tamer; Ngo, Huyen Thi; Vu, Tran Le-Huy; Sang, To Kim; Campos-Alberto, Eduardo; Sayed, Abdelrahman; Mizukami, Shusaku; Na-Bangchang, Kesara; Huy, Nguyen Tien; Hirayama, Kenji; Karbwang, Juntra.
Afiliación
  • Lemma MT; Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
  • Ahmed AM; Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt. Electronic address: ali.mahmoud@azhar.edu.eg.
  • Elhady MT; Faculty of Medicine, Zagazig University, Sharkia, 44511, Egypt.
  • Ngo HT; Department of Medicine, University of Medicine and Pharmacy, Ho Chi Minh city, Viet Nam.
  • Vu TL; Advanced Research Center Inc., 1020 S Anaheim Blvd, Anaheim, CA, United States.
  • Sang TK; Ho Chi Minh City Oncology Hospital, Ho Chi Minh City, Viet Nam.
  • Campos-Alberto E; Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
  • Sayed A; Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
  • Mizukami S; Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address: mizukami@nagasaki-u.ac.jp.
  • Na-Bangchang K; Graduate Studies, Chulabhorn International College of Medicine, Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Pathum Thani 12121, Thailand.
  • Huy NT; Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan; Evidence Based Medicine Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City
  • Hirayama K; Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address: hiraken@nagasaki-u.ac.jp.
  • Karbwang J; Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address: karbwangj@nagasaki-u.ac.jp.
Parasitol Int ; 66(6): 713-720, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28890153
The increasing resistance of malaria to drugs raise the need to new antimalarial agents. Antiplasmodial herbs and their active compounds are the most promising source the new antimalarial agents. This study aimed to identify the medicinal plants with very good in vitro antiplasmodial activities, with half-maximal inhibitory concentration (IC50)≤1µg/ml, and to determine trends in the process of screening their antiplasmodial activities. A total of 58 reports published in the English language were retrieved from the bibliographical databases. Screening and data extraction were performed by two independent reviewers. The herbs were categorized as very good, good, moderate and inactive if the IC50 values were <0.1µg/ml, 0.1-1µg/ml, >1-5µg/ml and >5µg/ml respectively. We documented 752 medicinal plants belonging to 254 genera. The majority of the plants were reported from Africa followed by Asia. The traditional use for malaria treatment was the most common reason for the selection of the plants for investigation. About 80% of the plants experimented were reported to be inactive. Among plants identified as having very good to good antiplasmodial crude extracts are Harungana madagascariensis, Quassia africana, and Brucea javanica, while Picrolemma spruce, Aspidosperma vargasi, Aspidosperma desmanthum, and Artemisia annua were reported to have individual compound isolates with very good antiplasmodial activities. In conclusion, the number of plant species assessed so far is still small compared with the stock in nature's plant library. A mechanism of systematically approaching and exploring the untouched plant genera needs to be designed.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Plasmodium / Malaria / Antimaláricos Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Parasitol Int Asunto de la revista: PARASITOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Plasmodium / Malaria / Antimaláricos Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Parasitol Int Asunto de la revista: PARASITOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos