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Association between objective signs and subjective symptoms of dry eye disease in patients with systemic sclerosis.
Rentka, Aniko; Nagy, Annamaria; Harsfalvi, Jolan; Szucs, Gabriella; Szekanecz, Zoltan; Gesztelyi, Rudolf; Szodoray, Peter; Kemeny-Beke, Adam.
Afiliación
  • Rentka A; Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Nagy A; Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Harsfalvi J; Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, 1094, Budapest, Hungary.
  • Szucs G; Department of Rheumatology, Faculty of Medicine, Institute of Medicine, Nagyerdei krt. 98, 4012, Debrecen, Hungary.
  • Szekanecz Z; Department of Rheumatology, Faculty of Medicine, Institute of Medicine, Nagyerdei krt. 98, 4012, Debrecen, Hungary.
  • Gesztelyi R; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Szodoray P; Institute of Immunology, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway.
  • Kemeny-Beke A; Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary. kemenyba@med.unideb.hu.
Rheumatol Int ; 37(11): 1835-1845, 2017 Nov.
Article en En | MEDLINE | ID: mdl-28884335
The aim of this study was to evaluate the association between clinical signs and symptoms of dry eye disease (DED) in patients with systemic sclerosis (SSc). This cross-sectional observational study included 19 SSc patients and 19 normal subjects with no ocular symptoms or ocular surface disorders. Clinical parameters included tear film break-up time (tBUT), Schirmer I, lissamine green (LG) dye, and tear film osmolarity tests, tear production, and tear secretion flow. For assessment of the dry eye symptoms, the Ocular Surface Disease Index (OSDI) questionnaire was administered to all patients. The following mean values were found in SSc patients: OSDI 33.6 ± 19.86; osmolarity of the tear fluid 310.8 mOsmol/l ± 14.47; tBUT time 5.158 ± 2.328 s; Schirmer I test 5.395 mm/5 min; LG grading score 2.026 ± 0.8893; collected tear fluid volume 6.397 ± 2.761 µl. The calculated average tear velocity was 4.654 ± 1.963 µl/min. A significant correlation was found between the OSDI as a subjective parameter and disease duration. Early recognition of dry eye symptoms, a possible extra-intestinal manifestation of SSc, should be included in the check up of the disease to reduce ocular complications. The objective tear functional tests were strongly influenced by individual factors like age and disease duration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Síndromes de Ojo Seco Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatol Int Año: 2017 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Síndromes de Ojo Seco Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatol Int Año: 2017 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Alemania