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Circulating miR-122 and miR-200a as biomarkers for fatal liver disease in ART-treated, HIV-1-infected individuals.
Murray, Daniel D; Suzuki, Kazuo; Law, Matthew; Trebicka, Jonel; Neuhaus Nordwall, Jacquie; Johnson, Margaret; Vjecha, Michael J; Kelleher, Anthony D; Emery, Sean.
Afiliación
  • Murray DD; The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia. dmurray@kirby.unsw.edu.au.
  • Suzuki K; The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.
  • Law M; The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.
  • Trebicka J; Department of Internal Medicine, University of Bonn, Bonn, Germany.
  • Neuhaus Nordwall J; University of Minnesota, Minneapolis, Minnesota, United States of America.
  • Johnson M; Ian Charleson Day Centre, Royal Free Hampstead NHS Trust, London, United Kingdom.
  • Vjecha MJ; Institute for Clinical Research, Veterans Affairs Medical Center, Washington D.C., United States of America.
  • Kelleher AD; The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.
  • Emery S; The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.
Sci Rep ; 7(1): 10934, 2017 09 07.
Article en En | MEDLINE | ID: mdl-28883647
Liver disease is one of the main contributors to the increased levels of morbidity and mortality seen in the HIV-1-infected, ART-treated population. Circulating miRNAs, particularly those located inside extracellular vesicles, are seen as promising biomarkers for a number of human disease conditions, including liver-related diseases. Here, we show that serum levels of miR-122 and miR-200a are greater in HIV/HCV co-infected individuals compared to HIV-1 mono-infected individuals. We also show that miR-122 and miR-200a are elevated in ART-treated, HIV-1-infected individuals prior to the development of fatal liver disease, suggesting that these miRNA may have some potential clinical utility as biomarkers. While this study is hypothesis generating, it shows clearly that both miR-122 and miR-200a are promising novel biomarkers for liver disease in the ART-treated, HIV-1-infected population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Infecciones por VIH / Hepatitis C Crónica / MicroARNs / Antirretrovirales / Enfermedad Hepática en Estado Terminal Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Infecciones por VIH / Hepatitis C Crónica / MicroARNs / Antirretrovirales / Enfermedad Hepática en Estado Terminal Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido