Downstream drug product processing of itraconazole nanosuspension: Factors influencing tablet material properties and dissolution of compacted nanosuspension-layered sugar beads.
Int J Pharm
; 532(1): 131-138, 2017 Oct 30.
Article
en En
| MEDLINE
| ID: mdl-28859940
There has been limited research done on the downstream processing of nanosuspensions into solid oral dosage forms. This paper demonstrates the bead layering process with a layering level at 150% and 240%, as well as the selection and justification of the outer phase excipients for tabletability and disintegrating properties. In a previous study, an itraconazole nanosuspension stabilised by SDS and HPMC E5 was layered onto sugar beads with coating polymer HPMC VLV. In the current study, compression studies with these layered beads utilising the small bead size at 150% or 240% layering levels with outer phase cushioning excipients MCC, copovidone or isomalt were performed. Other excipients such as co-compressed crospovidone-PEG 4000; DCP functioning as a disintegrant; and HPC as a binder was also added. Target output variables were achieved with a balance between an adequate tensile strength and fast dissolution rate with a release of 99.0% (±1.0% SD) within 10min, which is in accordance with the FDA guidance for dissolution testing. The results show that the compaction of nanosuspension-layered beads is a suitable process for processing an itraconazole nanosuspension into a solid dosage form such as a compacted tablet without compromising on drug release.
Palabras clave
Compaction; Copovidone (PubChem CID: 270885); Crospovidone (PubChem CID: 6917); Dibasic calcium phosphate (PubChem CID: 24441); Downstream processing; Formulation; Hydroxy propyl methyl cellulose (PubChem CID: 57503849); Hydroxypropyl cellulose (PubChem CID: 71306830); Isomalt (PubChem CID: 3034828); Itraconazole (PubChem CID: 55283); Microcrystalline cellulose (PubChem CID: 14055602); Multiparticulate oral dosage forms; Nano milling; Nanoparticles; Nanosuspensions; Nanotechnology; Pellet layering; Poly ethylene glycol (PubChem CID: 174); Poor solubility; Processing; Sodium dodecyl sulfate (PubChem CID: 3423265)
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Itraconazol
/
Nanopartículas
Idioma:
En
Revista:
Int J Pharm
Año:
2017
Tipo del documento:
Article
País de afiliación:
Singapur
Pais de publicación:
Países Bajos