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Imaging Human Brain Perfusion with Inhaled Hyperpolarized 129Xe MR Imaging.
Rao, Madhwesha R; Stewart, Neil J; Griffiths, Paul D; Norquay, Graham; Wild, Jim M.
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  • Rao MR; From the Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, C Floor, Sheffield S10 2JF, England (M.R.R., N.J.S., P.D.G., G.N., J.M.W.).
  • Stewart NJ; From the Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, C Floor, Sheffield S10 2JF, England (M.R.R., N.J.S., P.D.G., G.N., J.M.W.).
  • Griffiths PD; From the Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, C Floor, Sheffield S10 2JF, England (M.R.R., N.J.S., P.D.G., G.N., J.M.W.).
  • Norquay G; From the Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, C Floor, Sheffield S10 2JF, England (M.R.R., N.J.S., P.D.G., G.N., J.M.W.).
  • Wild JM; From the Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, C Floor, Sheffield S10 2JF, England (M.R.R., N.J.S., P.D.G., G.N., J.M.W.).
Radiology ; 286(2): 659-665, 2018 02.
Article en En | MEDLINE | ID: mdl-28858563
Purpose To evaluate the feasibility of directly imaging perfusion of human brain tissue by using magnetic resonance (MR) imaging with inhaled hyperpolarized xenon 129 (129Xe). Materials and Methods In vivo imaging with 129Xe was performed in three healthy participants. The combination of a high-yield spin-exchange optical pumping 129Xe polarizer, custom-built radiofrequency coils, and an optimized gradient-echo MR imaging protocol was used to achieve signal sensitivity sufficient to directly image hyperpolarized 129Xe dissolved in the human brain. Conventional T1-weighted proton (hydrogen 1 [1H]) images and perfusion images by using arterial spin labeling were obtained for comparison. Results Images of 129Xe uptake were obtained with a signal-to-noise ratio of 31 ± 9 and demonstrated structural similarities to the gray matter distribution on conventional T1-weighted 1H images and to perfusion images from arterial spin labeling. Conclusion Hyperpolarized 129Xe MR imaging is an injection-free means of imaging the perfusion of cerebral tissue. The proposed method images the uptake of inhaled xenon gas to the extravascular brain tissue compartment across the intact blood-brain barrier. This level of sensitivity is not readily available with contemporary MR imaging methods. ©RSNA, 2017.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isótopos de Xenón / Encéfalo / Medios de Contraste Tipo de estudio: Evaluation_studies Límite: Adult / Humans / Male Idioma: En Revista: Radiology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isótopos de Xenón / Encéfalo / Medios de Contraste Tipo de estudio: Evaluation_studies Límite: Adult / Humans / Male Idioma: En Revista: Radiology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos