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Intraoperative dexamethasone alters immune cell populations in patients undergoing elective laparoscopic gynaecological surgery.
Corcoran, T; Paech, M; Law, D; Muchatuta, N A; French, M; Ho, K M.
Afiliación
  • Corcoran T; Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, Western Australia.
  • Paech M; School of Medicine and Pharmacology, University of Western Australia.
  • Law D; Western Australia Health Department; Perth, Western Australia.
  • Muchatuta NA; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
  • French M; Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, Western Australia.
  • Ho KM; School of Medicine and Pharmacology, University of Western Australia.
Br J Anaesth ; 119(2): 221-230, 2017 Aug 01.
Article en En | MEDLINE | ID: mdl-28854534
BACKGROUND: Anaesthetists use dexamethasone principally for its anti-emetic effect. The purpose of this study was to characterize the effects of a single intraoperative dose of dexamethasone on cellular and metabolic components of the immune system in patients undergoing laparoscopic surgical procedures. METHODS: In this prospective double-blind trial, female patients undergoing elective major laparoscopic surgery were randomized to receive saline (Control group, n =16) or dexamethasone 4 mg (Dexamethasone group, n =16) i.v. after the induction of anaesthesia. Inflammatory markers and immune cell counts were examined at 24 and 48 h and 6 weeks after surgery. The changes from baseline preoperative values were compared between groups using a Mann-Whitney U -test, and linear mixed models were used to validate the findings. RESULTS: No differences in concentrations of serum glucose and interleukin-6 were observed between groups after surgery. The increase in C-reactive protein concentration at 24 h after surgery was greater in the control group [median (interquartile range), 33 (25-65) vs 17 (7-26) mg dl -1 ; P =0.018]. Extensive changes in the counts of white cells, including most lymphocyte subsets, were observed 24 h after surgery, and dexamethasone appeared to attenuate most of these changes. Changes at 48 h and 6 weeks did not differ between groups. CONCLUSIONS: In female patients undergoing elective laparoscopic gynaecological surgery, dexamethasone administration appears to attenuate inflammation and to alter immune cell counts at 24 h, with no effects identified after this time. The importance of these changes for postoperative immune function is unknown. TRIAL REGISTRATION: Australia and New Zealand Clinical Trials Registry (ACTRN12608000340336).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos Quirúrgicos Ginecológicos / Dexametasona / Laparoscopía / Procedimientos Quirúrgicos Electivos / Leucocitos / Antieméticos Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Br J Anaesth Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos Quirúrgicos Ginecológicos / Dexametasona / Laparoscopía / Procedimientos Quirúrgicos Electivos / Leucocitos / Antieméticos Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Br J Anaesth Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido