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Taurine Attenuates Doxorubicin-Induced Toxicity on B16F10 Cells.
Kim, Yon-Suk; Kim, Eun-Kyung; Hwang, Jin-Woo; Kim, Won-Suk; Shin, Woen-Bin; Natarajan, Sithranga Boopathy; Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam.
Afiliación
  • Kim YS; Department of Biotechnology, Konkuk University, Chungju, 27478, South Korea.
  • Kim EK; Korea Nokyong Research Center, Konkuk University, Chungju, 27478, South Korea.
  • Hwang JW; Division of Food Bio Science, Konkuk University, Chungju, 27478, South Korea.
  • Kim WS; Department of Biotechnology, Konkuk University, Chungju, 27478, South Korea.
  • Shin WB; Department of Pharmaceutical Engineering, Silla University, Busan, 46958, South Korea.
  • Natarajan SB; Department of Biotechnology, Konkuk University, Chungju, 27478, South Korea.
  • Moon SH; Department of Biotechnology, Konkuk University, Chungju, 27478, South Korea.
  • Jeon BT; Korea Nokyong Research Center, Konkuk University, Chungju, 27478, South Korea.
  • Park PJ; Korea Nokyong Research Center, Konkuk University, Chungju, 27478, South Korea.
Adv Exp Med Biol ; 975 Pt 2: 1179-1190, 2017.
Article en En | MEDLINE | ID: mdl-28849532
This study aimed to investigate the effect of doxorubicin co-treatment with taurine on B16F10 melanoma cells. Frequently, Doxorubicin is used in the treatments of many different kinds of cancers, some of which are soft tissue sarcomas, hematological malignancies and carcinomas. However, the clinical application of doxorubicin is compromised by its severe adverse effects, including cardiotoxicity. In the present study, the efficacy of doxorubicin co-treatment with taurine was investigated. B16F10 cell viability was evaluated using MTT assays, trypan blue dye exclusion assays, and fluorescent staining technique. Apoptotic cells were detected by flow cytometry and the proteins associated with apoptosis and cellular differentiations were assessed by immunoblotting. Doxorubicin inhibited cell growth and induced cell death in B16F10 cells. Interestingly, doxorubicin co-treatment with taurine inhibited apoptosis in B16F10 cells. These results indicate that doxorubicin co-treatment with taurine attenuates doxorubicin-induced cytotoxicity and reduces ROS production in B16F10 cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Taurina / Doxorrubicina / Apoptosis / Estrés Oxidativo / Antibióticos Antineoplásicos Límite: Animals Idioma: En Revista: Adv Exp Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Taurina / Doxorrubicina / Apoptosis / Estrés Oxidativo / Antibióticos Antineoplásicos Límite: Animals Idioma: En Revista: Adv Exp Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos