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Comparative Analysis of Microbicidal and Anti-inflammatory Properties of Novel Taurine Bromamine Derivatives and Bromamine T.
Walczewska, M; Perun, A; Bialecka, A; Sróttek, M; Jamróz, W; Dorozynski, P; Jachowicz, R; Kulinowski, P; Nagl, M; Gottardi, W; Marcinkiewicz, J.
Afiliación
  • Walczewska M; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland.
  • Perun A; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland.
  • Bialecka A; Center of Microbiological research and Autovaccines Ltd., Krakow, Poland.
  • Sróttek M; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland.
  • Jamróz W; Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Krakow, Poland.
  • Dorozynski P; Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Krakow, Poland.
  • Jachowicz R; Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Krakow, Poland.
  • Kulinowski P; Institute of Technology, Pedagogical University of Cracow, Krakow, Poland.
  • Nagl M; Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Gottardi W; Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Marcinkiewicz J; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland. mmmarcin@cyf-kr.edu.pl.
Adv Exp Med Biol ; 975 Pt 1: 515-534, 2017.
Article en En | MEDLINE | ID: mdl-28849479
Taurine, the most abundant free amino acid in leukocyte cytosol traps hypohalous acids (HOCl and HOBr) to produce N-chlorotaurine (taurine chloramine, NCT and N-bromotaurine (taurine bromamine, Tau-NHBr,) respectively. Both haloamines show anti-inflammatory and antimicrobial properties. However, the therapeutic applicability of Tau-NHBr is limited due to its relatively poor stability. To overcome this disadvantage, we have synthesized the stable N-bromotaurine compounds N-monobromo-2,2-dimethyltaurine (Br-612) and N-dibromo-2,2-dimethyltaurine (Br-422). The aim of this study was to compare anti-inflammatory and microbicidal properties of Br-612 and Br-422 with that of Tau-NHBr and bromamine T (BAT). We have shown that all the tested compounds show similar anti-inflammatory properties. Importantly, the stable N-bromotaurine compounds exerted even stronger microbicidal activity than Tau-NHBr. Finally, for the purpose of topical application of these compounds we have developed a carbomer-based bioadhesive solid dosage form of BAT and Br-612, featuring sustained release of the active substance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Taurina / Bromuros / Antiinfecciosos / Antiinflamatorios Límite: Animals Idioma: En Revista: Adv Exp Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Taurina / Bromuros / Antiinfecciosos / Antiinflamatorios Límite: Animals Idioma: En Revista: Adv Exp Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos