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Perinatal Taurine Supplementation Prevents Metabolic and Cardiovascular Effects of Maternal Diabetes in Adult Rat Offspring.
Thaeomor, Atcharaporn; Teangphuck, Punyaphat; Chaisakul, Janeyuth; Seanthaweesuk, Suphaket; Somparn, Nuntiya; Roysommuti, Sanya.
Afiliación
  • Thaeomor A; School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
  • Teangphuck P; School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
  • Chaisakul J; Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.
  • Seanthaweesuk S; Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathumthani, 12120, Thailand.
  • Somparn N; Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathumthani, 12120, Thailand.
  • Roysommuti S; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. sanya@kku.ac.th.
Adv Exp Med Biol ; 975 Pt 1: 295-305, 2017.
Article en En | MEDLINE | ID: mdl-28849464
This study tests the hypothesis that perinatal taurine supplementation prevents diabetes mellitus and hypertension in adult offspring of maternal diabetic rats. Female Wistar rats were fed normal rat chow and tap water with (Diabetes group) or without diabetic induction by intraperitoneal streptozotocin injection (Control group) before pregnancy. Then, they were supplemented with 3% taurine in water (Control+T and Diabetes+T groups) or water alone from conception to weaning. After weaning, both male and female offspring were fed normal rat chow and tap water throughout the study. Blood chemistry and cardiovascular parameters were studied in 16-week old rats. Body, heart, and kidney weights were not significantly different among the eight groups. Further, lipid profiles except triglyceride were not significantly different among male and female groups, while male Diabetes displayed increased fasting blood glucose, decreased plasma insulin, and increased plasma triglyceride compared to other groups. Compared to Control, mean arterial pressures significantly increased and baroreflex control of heart rate decreased in both male and female Diabetes, while heart rates significantly decreased in male but increased in female Diabetes group. Although perinatal taurine supplementation did not affect any measured parameters in Control groups, it abolished the adverse effects of maternal diabetes on fasting blood glucose, plasma insulin, lipid profiles, mean arterial pressure, heart rate, and baroreflex sensitivity in adult male and female offspring. The present study indicates that maternal diabetes mellitus induces metabolic and cardiovascular defects more in male than female adult offspring, and these adverse effects can be prevented by perinatal taurine supplementation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Taurina / Barorreflejo / Diabetes Mellitus Experimental Límite: Animals / Pregnancy Idioma: En Revista: Adv Exp Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Taurina / Barorreflejo / Diabetes Mellitus Experimental Límite: Animals / Pregnancy Idioma: En Revista: Adv Exp Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos